Literature DB >> 8973052

A method to estimate in vivo D2 receptor occupancy by antipsychotic drugs.

R A Roemer1, E Richelson, C Shagass, L Leventhal.   

Abstract

A computational method is presented to estimate in vivo receptor occupancies of frequently used antipsychotic medications, which may provide a way to determine their central nervous system (CNS) effects in humans. The method can be used to estimate occupancies of several receptor types based on the daily dose of antipsychotic medication. Estimates of D2 receptor occupancy by haloperidol based on this equation were compared with those yielded by positron emission tomography (PET) measures in humans for the same compounds and dosages: the results of this comparison validated the approach.

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Year:  1996        PMID： 8973052      PMCID： PMC1188797     

Source DB:  PubMed          Journal:  J Psychiatry Neurosci        ISSN： 1180-4882            Impact factor:   6.186


  48 in total

1.  Drug distribution between blood and brain as a determinant of antipsychotic drug effects.

Authors:  T Tsuneizumi; S M Babb; B M Cohen
Journal:  Biol Psychiatry       Date:  1992-11-01       Impact factor: 13.382

2.  Pharmacokinetic protocol for predicting plasma haloperidol concentrations.

Authors:  D D Miller; P J Perry; M W Kelly; W H Coryell; S V Arndt
Journal:  J Clin Psychopharmacol       Date:  1990-06       Impact factor: 3.153

3.  Correction of serum neuroleptic activity for blood-to-brain distribution: a method that may render radioreceptor assay results comparable between neuroleptics.

Authors:  A S Young; S V Faraone; W A Brown
Journal:  J Clin Psychopharmacol       Date:  1989-10       Impact factor: 3.153

4.  Striatal dopamine receptor occupancy during and following withdrawal from neuroleptic treatment: correlative evaluation by positron emission tomography and plasma prolactin levels.

Authors:  J C Baron; J L Martinot; H Cambon; J P Boulenger; M F Poirier; V Caillard; J Blin; J D Huret; C Loc'h; B Maziere
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

5.  Relation of serum molindone levels to serum prolactin levels and antipsychotic response.

Authors:  A K Pandurangi; N Narasimhachari; W G Blackard; B S Landa
Journal:  J Clin Psychiatry       Date:  1989-10       Impact factor: 4.384

6.  Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia.

Authors:  A Wolkin; F Barouche; A P Wolf; J Rotrosen; J S Fowler; C Y Shiue; T B Cooper; J D Brodie
Journal:  Am J Psychiatry       Date:  1989-07       Impact factor: 18.112

7.  Haloperidol and reduced haloperidol plasma levels in Chinese vs. non-Chinese psychiatric patients.

Authors:  M W Jann; W H Chang; C M Davis; T Y Chen; H C Deng; F W Lung; L Ereshefsky; S R Saklad; A L Richards
Journal:  Psychiatry Res       Date:  1989-10       Impact factor: 3.222

8.  Plasma levels of parent drug and metabolites in patients receiving oral and depot fluphenazine.

Authors:  S R Marder; T Van Putten; M Aravagiri; J W Hubbard; E M Hawes; G McKay; K K Midha
Journal:  Psychopharmacol Bull       Date:  1989

9.  A fixed dose study of the plasma concentration and clinical effects of thioridazine and its major metabolites.

Authors:  B M Cohen; J F Lipinski; C Waternaux
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

10.  Trifluoperazine plasma levels and clinical response.

Authors:  P G Janicak; J I Javaid; R P Sharma; J E Comaty; J Peterson; J M Davis
Journal:  J Clin Psychopharmacol       Date:  1989-10       Impact factor: 3.153
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  1 in total

1.  Combining the Antipsychotic Drug Haloperidol and Environmental Enrichment after Traumatic Brain Injury Is a Double-Edged Sword.

Authors:  Kaitlin A Folweiler; Corina O Bondi; Elizabeth A Ogunsanya; Megan J LaPorte; Jacob B Leary; Hannah L Radabaugh; Christina M Monaco; Anthony E Kline
Journal:  J Neurotrauma       Date:  2016-04-20       Impact factor: 5.269
  1 in total

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