Literature DB >> 8973051

Enhanced calcium response to serotonin in platelets from patients with affective disorders.

S Yamawaki1, A Kagaya, Y Okamoto, M Shimizu, A Nishida, Y Uchitomi.   

Abstract

In this report we have investigated the intracellular calcium (Ca2+) mobilization mediated by serotonin 5-HT2A receptors in the platelets of 13 patients with bipolar disorder and 12 patients with major depression in comparison with 15 healthy control subjects. We found an enhanced intracellular Ca2+ rise in response to 5-HT in platelets from both bipolar patients and patients with major depression. The 5-HT2A receptor-mediated intracellular Ca2+ signaling mechanism may have an important role in the pathophysiology of affective disorders.

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Year:  1996        PMID： 8973051      PMCID： PMC1188796     

Source DB:  PubMed          Journal:  J Psychiatry Neurosci        ISSN： 1180-4882            Impact factor:   6.186


  20 in total

1.  Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls.

Authors:  C H Tan; M A Javors; E Seleshi; P A Lowrimore; C L Bowden
Journal:  Life Sci       Date:  1990       Impact factor: 5.037

2.  Serotonin but not norepinephrine-induced calcium mobilization of platelets is enhanced in affective disorders.

Authors:  M Mikuni; A Kagaya; K Takahashi; H Y Meltzer
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

3.  5HT2 receptor changes in major depression.

Authors:  M Yates; A Leake; J M Candy; A F Fairbairn; I G McKeith; I N Ferrier
Journal:  Biol Psychiatry       Date:  1990-03-01       Impact factor: 13.382

4.  Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects.

Authors:  R C Arora; H Y Meltzer
Journal:  Am J Psychiatry       Date:  1989-06       Impact factor: 18.112

5.  Increased platelet intracellular calcium concentration in patients with bipolar affective disorders.

Authors:  S L Dubovsky; J Christiano; L C Daniell; R D Franks; J Murphy; L Adler; N Baker; R A Harris
Journal:  Arch Gen Psychiatry       Date:  1989-07

Review 6.  The second-messenger dysbalance hypothesis of affective disorders.

Authors:  H Wachtel
Journal:  Pharmacopsychiatry       Date:  1990-01       Impact factor: 5.788

7.  Increased 5-HT-2 receptor function as measured by serotonin-stimulated phosphoinositide hydrolysis in platelets of depressed patients.

Authors:  M Mikuni; I Kusumi; A Kagaya; Y Kuroda; H Mori; K Takahashi
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  1991       Impact factor: 5.067

8.  Serotonin 5-HT2 receptor binding on blood platelets--a peripheral marker for depression?

Authors:  A Biegon; A Weizman; L Karp; A Ram; S Tiano; M Wolff
Journal:  Life Sci       Date:  1987-11-30       Impact factor: 5.037

9.  Increased serotonin2 (5-HT2) receptor binding as measured by 3H-lysergic acid diethylamide (3H-LSD) in the blood platelets of depressed patients.

Authors:  R C Arora; H Y Meltzer
Journal:  Life Sci       Date:  1989       Impact factor: 5.037

10.  Platelet serotonin-2 receptor binding sites in depression and suicide.

Authors:  G N Pandey; S C Pandey; P G Janicak; R C Marks; J M Davis
Journal:  Biol Psychiatry       Date:  1990-08-01       Impact factor: 13.382
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  3 in total

1.  Effects of dextroamphetamine, lithium chloride, sodium valproate and carbamazepine on intraplatelet Ca2+ levels.

Authors:  Michele L Ulrich; Susan Rotzinger; Sheila J Asghar; Paul Jurasz; Veronique A Tanay; Susan M J Dunn; Marek Radomski; Andy Greenshaw; Peter H Silverstone
Journal:  J Psychiatry Neurosci       Date:  2003-03       Impact factor: 6.186

2.  Effects of valproate on serotonin-induced intracellular calcium mobilization in human platelets.

Authors:  Tatsuyuki Akimoto; Ichiro Kusumi; Katsuji Suzuki; Takuya Masui; Tsukasa Koyama
Journal:  J Psychiatry Neurosci       Date:  2007-01       Impact factor: 6.186

Review 3.  Upstream Pathways Controlling Mitochondrial Function in Major Psychosis: A Focus on Bipolar Disorder.

Authors:  Alencar Kolinski Machado; Alexander Yongshuai Pan; Tatiane Morgana da Silva; Angela Duong; Ana Cristina Andreazza
Journal:  Can J Psychiatry       Date:  2016-05-09       Impact factor: 4.356
  3 in total

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