| Literature DB >> 8971479 |
Abstract
The cytokine Eta-1/osteopontin is secreted by activated macrophages and may constitute the most abundant molecule secreted by activated T-lymphocytes. It causes macrophages to migrate and suppress production of reactive oxygen species. It enhances generation of immunoglobulins or proliferation of B-lymphocytes. Its biochemical characteristics suggest that Eta-1/osteopontin may be the T-lymphocyte suppressor factor. The apparently conflicting effects on individual immune functions may reflect homeostatic mechanisms.Entities:
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Year: 1996 PMID: 8971479 DOI: 10.1016/s1359-6101(96)00030-5
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN: 1359-6101 Impact factor: 7.638