Literature DB >> 8971036

Characterization of the spliced pol transcript of feline foamy virus: the splice acceptor site of the pol transcript is located in gag of foamy viruses.

J Bodem1, M Löchelt, I Winkler, R P Flower, H Delius, R M Flügel.   

Abstract

Foamy viruses, or spumaviruses, are distinct members of the Retroviridae. Here we have characterized the long terminal repeat of the feline, or cat, foamy virus by determining the locations of the transcriptional start site and the poly(A) addition site. The splice donor and splice acceptor sites of the subgenomic mRNA responsible for Pro-Pol protein expression were identified by nucleotide sequencing of the corresponding cDNAs. The leader exon of the feline foamy virus is 57 nucleotides long. The splice acceptor of the subgenomic pol mRNA was found to be located in gag. The location of the splice acceptor of the human foamy virus pol mRNA was confirmed to map in gag. The pol splice acceptor site in gag of the cat foamy virus is located further downstream than that of human foamy virus.

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Year:  1996        PMID： 8971036      PMCID： PMC191004     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  9 in total

1.  Novel internal promoter/enhancer of HTLV-I for Tax expression.

Authors:  T Nosaka; Y Ariumi; M Sakurai; R Takeuchi; M Hatanaka
Journal:  Nucleic Acids Res       Date:  1993-11-11       Impact factor: 16.971

2.  Human foamy virus genome possesses an internal, Bel-1-dependent and functional promoter.

Authors:  M Löchelt; W Muranyi; R M Flügel
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205

3.  Construction of an infectious DNA clone of the full-length human spumaretrovirus genome and mutagenesis of the bel 1 gene.

Authors:  M Löchelt; H Zentgraf; R M Flügel
Journal:  Virology       Date:  1991-09       Impact factor: 3.616

4.  The human foamy virus pol gene is expressed as a Pro-Pol polyprotein and not as a Gag-Pol fusion protein.

Authors:  M Löchelt; R M Flügel
Journal:  J Virol       Date:  1996-02       Impact factor: 5.103

5.  Human foamy virus replication: a pathway distinct from that of retroviruses and hepadnaviruses.

Authors:  S F Yu; D N Baldwin; S R Gwynn; S Yendapalli; M L Linial
Journal:  Science       Date:  1996-03-15       Impact factor: 47.728

6.  Genomic organization and expression of simian foamy virus type 3 (SFV-3).

Authors:  R Renne; E Friedl; M Schweizer; U Fleps; R Turek; D Neumann-Haefelin
Journal:  Virology       Date:  1992-02       Impact factor: 3.616

7.  Foamy virus reverse transcriptase is expressed independently from the Gag protein.

Authors:  J Enssle; I Jordan; B Mauer; A Rethwilm
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-30       Impact factor: 11.205

8.  Simian foamy virus type 1 is a retrovirus which encodes a transcriptional transactivator.

Authors:  A Mergia; K E Shaw; E Pratt-Lowe; P A Barry; P A Luciw
Journal:  J Virol       Date:  1990-08       Impact factor: 5.103

9.  Detection and prevalence of serotypes of feline syncytial spumaviruses.

Authors:  R L Flower; G E Wilcox; R D Cook; T M Ellis
Journal:  Arch Virol       Date:  1985       Impact factor: 2.574
  9 in total
  34 in total

Review 1.  Molecular biology of foamy viruses.

Authors:  Axel Rethwilm
Journal:  Med Microbiol Immunol       Date:  2010-05-06       Impact factor: 3.402

2.  RNA and protein requirements for incorporation of the Pol protein into foamy virus particles.

Authors:  Katrin Peters; Tatiana Wiktorowicz; Martin Heinkelein; Axel Rethwilm
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

3.  Carboxy-terminal cleavage of the human foamy virus Gag precursor molecule is an essential step in the viral life cycle.

Authors:  J Enssle; N Fischer; A Moebes; B Mauer; U Smola; A Rethwilm
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

Review 4.  Foamy viruses are unconventional retroviruses.

Authors:  M L Linial
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

5.  Regulation of foamy virus protease activity by viral RNA: a novel and unique mechanism among retroviruses.

Authors:  Maximilian J Hartl; Jochen Bodem; Fabian Jochheim; Axel Rethwilm; Paul Rösch; Birgitta M Wöhrl
Journal:  J Virol       Date:  2011-02-16       Impact factor: 5.103

6.  Molecular characterization of proteolytic processing of the Gag proteins of human spumavirus.

Authors:  K I Pfrepper; M Löchelt; H R Rackwitz; M Schnölzer; H Heid; R M Flügel
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

7.  Feline foamy virus genome and replication strategy.

Authors:  Jacqueline Roy; Wolfram Rudolph; Thomas Juretzek; Kathleen Gärtner; Michael Bock; Ottmar Herchenröder; Dirk Lindemann; Martin Heinkelein; Axel Rethwilm
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

8.  Evidence that the human foamy virus genome is DNA.

Authors:  S F Yu; M D Sullivan; M L Linial
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

9.  Molecular characterization of proteolytic processing of the Pol proteins of human foamy virus reveals novel features of the viral protease.

Authors:  K I Pfrepper; H R Rackwitz; M Schnölzer; H Heid; M Löchelt; R M Flügel
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

10.  Restriction of foamy viruses by primate Trim5alpha.

Authors:  Melvyn W Yap; Dirk Lindemann; Nicole Stanke; Juliane Reh; Dana Westphal; Helmut Hanenberg; Sadayuki Ohkura; Jonathan P Stoye
Journal:  J Virol       Date:  2008-03-26       Impact factor: 5.103
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