Literature DB >> 8970056

Methotrexate osteopathy, does it exist?

K Maenaut1, R Westhovens, J Dequeker.   

Abstract

We describe 2 postmenopausal women with rheumatoid arthritis (RA). They developed fractures during their treatment with weekly low dose methotrexate (MTX). The adverse effect of longterm low dose regimens of MTX on bone metabolism has been described as "methotrexate osteopathy," an analogy of the syndrome known in pediatric oncology. MTX may be an additional risk factor for osteoporosis and fractures in RA. This therapy should be relatively contraindicated in patients with multiple risk factors for osteoporosis.

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Year:  1996        PMID： 8970056

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  6 in total

1.  Medial tibial stress syndrome due to methotrexate osteopathy.

Authors:  P Alonso-Bartolome; V M Martinez-Taboada; A Canga; R Blanco
Journal:  Ann Rheum Dis       Date:  2006-06       Impact factor: 19.103

2.  Risk factors for vertebral fracture in menopausal or postmenopausal Japanese women with rheumatoid arthritis: a cross-sectional and longitudinal study.

Authors:  Katsumitsu Arai; Tadamasa Hanyu; Hiroya Sugitani; Takehiro Murai; Junichi Fujisawa; Kiyoshi Nakazono; Naoki Kondo; Naoto Endo
Journal:  J Bone Miner Metab       Date:  2006       Impact factor: 2.626

Review 3.  Methotrexate osteopathy: five cases and systematic literature review.

Authors:  F Robin; S Cadiou; J-D Albert; G Bart; G Coiffier; P Guggenbuhl
Journal:  Osteoporos Int       Date:  2020-10-30       Impact factor: 4.507

4.  Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients.

Authors:  Wako Urano; Takefumi Furuya; Eisuke Inoue; Atsuo Taniguchi; Tomohiko Urano; Shigeru Kotake; Chieko Sekita; Satoshi Inoue; Masako Hara; Shigeki Momohara; Naoyuki Kamatani; Hisashi Yamanaka
Journal:  J Bone Miner Metab       Date:  2009-03-31       Impact factor: 2.626

5.  No deleterious effect of low dose methotrexate on titanium implant osseointegration in a rabbit model.

Authors:  Janaina Badin Carvas; Rosa Maria Rodrigues Pereira; Eloisa Bonfá; Celey Aparecida Silveira; Luiz Lapa Lima; Valéria de Falco Caparbo; Suzana Beatriz Veríssimo de Mello
Journal:  Clinics (Sao Paulo)       Date:  2011       Impact factor: 2.365

6.  An osteoporotic hip fracture in a 14-year-old girl undergoing chemotherapy and operated for knee osteosarcoma.

Authors:  Carmine Zoccali; Umberto Prencipe; Virginia Ferraresi; Nicola Salducca
Journal:  J Orthop Traumatol       Date:  2009-07-31
  6 in total

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