S J Wallis1, J Firth, W R Dunn. 1. Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen's Medical Centre, UK.
Abstract
BACKGROUND AND PURPOSE: Pressure-induced myogenic responses have been demonstrated in cerebral resistance arteries isolated from a number of species. In the present study, we determined the response of human isolated cerebral resistance arteries to a pressure stimulus. METHODS: Arteries were set up in a pressure myograph and exposed to alterations in intravascular pressure. RESULTS: Human isolated cerebral resistance arteries developed spontaneous intrinsic tone in response to a pressure stimulus over the pressure range of 20 to 90 mm Hg that was not apparent in the absence of extracellular calcium. This intrinsic tone may be an inherent property of the vascular smooth muscle, since it remained after functional removal of the endothelium. CONCLUSIONS: Human isolated cerebral resistance arteries spontaneously contract when exposed to raised intravascular pressure. This pressure-induced myogenic response may contribute to cerebral autoregulation of blood flow.
BACKGROUND AND PURPOSE: Pressure-induced myogenic responses have been demonstrated in cerebral resistance arteries isolated from a number of species. In the present study, we determined the response of human isolated cerebral resistance arteries to a pressure stimulus. METHODS: Arteries were set up in a pressure myograph and exposed to alterations in intravascular pressure. RESULTS:Human isolated cerebral resistance arteries developed spontaneous intrinsic tone in response to a pressure stimulus over the pressure range of 20 to 90 mm Hg that was not apparent in the absence of extracellular calcium. This intrinsic tone may be an inherent property of the vascular smooth muscle, since it remained after functional removal of the endothelium. CONCLUSIONS:Human isolated cerebral resistance arteries spontaneously contract when exposed to raised intravascular pressure. This pressure-induced myogenic response may contribute to cerebral autoregulation of blood flow.
Authors: E W Lang; J Lagopoulos; J Griffith; K Yip; A Yam; Y Mudaliar; H M Mehdorn; N W C Dorsch Journal: J Neurol Neurosurg Psychiatry Date: 2003-08 Impact factor: 10.154
Authors: Alexandra Mardimae; Dahlia Y Balaban; Matthew A Machina; Anne Battisti-Charbonney; Jay S Han; Rita Katznelson; Leonid L Minkovich; Ludwik Fedorko; Patricia M Murphy; Marcin Wasowicz; Finola Naughton; Massimiliano Meineri; Joseph A Fisher; James Duffin Journal: Pflugers Arch Date: 2012-09-09 Impact factor: 3.657
Authors: Claire M Nichols; Oleksandr V Povstyan; Anthony P Albert; Dmitry V Gordienko; Omar Khan; Georgios Vasilikostas; Teck K Khong; Andrew Wan; Marcus Reddy; Maksym I Harhun Journal: Purinergic Signal Date: 2014-05-22 Impact factor: 3.765