Synthesis of substituted benzoquinones and naphthoquinones with potential antituberculous activity.

Compounds were prepared through the reaction of benzoquinone, naphthoquinone and 2-methyl-1.4-naphthoquinone with several sulphonamides in common use. It is hoped that incorporation of these bacteriostatic agents with the high lipid solubility of the quinone used may afford a better bacteriostatic activity. Determination of the partition coefficient of some representative samples proved these compounds to have high lipid solubility.