Literature DB >> 8969033

Ketanserin in the treatment of protamine-induced pulmonary hypertension.

P J van der Starre1, C Solinas.   

Abstract

The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction. A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement. The potential role of serotonin in the development of this serious complication is discussed.

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Year:  1996        PMID： 8969033      PMCID： PMC325377     

Source DB:  PubMed          Journal:  Tex Heart Inst J        ISSN： 0730-2347


  20 in total

1.  Protamine reactions, explosive mediator release, and pulmonary vasoconstriction.

Authors:  E Lowenstein; W M Zapol
Journal:  Anesthesiology       Date:  1990-09       Impact factor: 7.892

2.  Hemodynamic changes after the administration of protamine.

Authors:  P A Casthely; K Goodman; P N Fyman; L M Abrams; D Aaron
Journal:  Anesth Analg       Date:  1986-01       Impact factor: 5.108

Review 3.  The role of serotonin blockers in cardiac anesthesia.

Authors:  P J Van der Starre; R S Reneman
Journal:  J Cardiothorac Vasc Anesth       Date:  1994-08       Impact factor: 2.628

4.  Protamine releases endothelium-derived relaxing factor from systemic arteries. A possible mechanism of hypotension during heparin neutralization.

Authors:  P J Pearson; P R Evora; K Ayrancioglu; H V Schaff
Journal:  Circulation       Date:  1992-07       Impact factor: 29.690

5.  Heparin prevents the vasodilating actions of protamine on human small mesenteric arteries.

Authors:  T Akata; K Kodama; J Yoshitake; S Takahashi
Journal:  Anesth Analg       Date:  1993-06       Impact factor: 5.108

6.  Prostaglandin E2, prostacyclin, and thromboxane changes during nonpulsatile cardiopulmonary bypass in humans.

Authors:  M E Faymonville; G Deby-Dupont; R Larbuisson; C Deby; L Bodson; R Limet; M Lamy
Journal:  J Thorac Cardiovasc Surg       Date:  1986-06       Impact factor: 5.209

7.  C5a and thromboxane generation associated with pulmonary vaso- and broncho-constriction during protamine reversal of heparin.

Authors:  D R Morel; W M Zapol; S J Thomas; E M Kitain; D R Robinson; J Moss; D E Chenoweth; E Lowenstein
Journal:  Anesthesiology       Date:  1987-05       Impact factor: 7.892

8.  Association of protamine IgE and IgG antibodies with life-threatening reactions to intravenous protamine.

Authors:  M E Weiss; D Nyhan; Z K Peng; J C Horrow; E Lowenstein; C Hirshman; N F Adkinson
Journal:  N Engl J Med       Date:  1989-04-06       Impact factor: 91.245

9.  [Ketanserin versus sodium nitroprusside in the treatment of hypertension following coronary surgery. Effect on intrapulmonary right and left shunt and arterial oxygenation].

Authors:  T Möllhoff; J P Mulier; E Müller; H Van Aken; P Lauwers
Journal:  Anaesthesist       Date:  1989-10       Impact factor: 1.041

10.  Inhaled nitric oxide. A selective pulmonary vasodilator of heparin-protamine vasoconstriction in sheep.

Authors:  M D Fratacci; C G Frostell; T Y Chen; J C Wain; D R Robinson; W M Zapol
Journal:  Anesthesiology       Date:  1991-12       Impact factor: 7.892
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  2 in total

Review 1.  Role of serotonin in the pathogenesis of acute and chronic pulmonary hypertension.

Authors:  P Egermayer; G I Town; A J Peacock
Journal:  Thorax       Date:  1999-02       Impact factor: 9.139

2.  Use of epoprostenol to treat severe pulmonary vasoconstriction induced by protamine in cardiac surgery.

Authors:  Zheng Guan; Xin Shen; Yong-Jian Zhang; Xiao-Gang Li; Yan-Feng Gao; Jing Tan; Hui Yuan; Jing-Jie Liu
Journal:  Medicine (Baltimore)       Date:  2018-07       Impact factor: 1.889
  2 in total

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