Literature DB >> 8962686

Homocysteinemia is a common feature of schizophrenia.

B Regland1, B V Johansson, B Grenfeldt, L T Hjelmgren, M Medhus.   

Abstract

A significant proportion of patients with schizophrenia have increased homocysteine levels that are unrelated to psychopharmacological medication or nutrient deficiency in folate or cobalamin. This supports the hypothesis that inherent methylation deficiency is involved in the pathogenesis of schizophrenia.

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Year:  1995        PMID： 8962686     DOI： 10.1007/bf01271539

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  10 in total

1.  Platelet methylene reductase activity in schizophrenia.

Authors:  P A Berger; G R Elliott; E Erdelyi; S J Watson; R J Wyatt; J D Barchas
Journal:  Arch Gen Psychiatry       Date:  1977-07

2.  Letter: Blood-levels of S-adenosylmethionine in schizophrenia.

Authors:  V M Andreoli; F Maffei
Journal:  Lancet       Date:  1975-11-08       Impact factor: 79.321

3.  Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity.

Authors:  J M Freeman; J D Finkelstein; S H Mudd
Journal:  N Engl J Med       Date:  1975-03-06       Impact factor: 91.245

4.  Abnormalities of one-carbon metabolism in psychiatric disorders: study of methionine adenosyltransferase kinetics and lipid composition of erythrocyte membranes.

Authors:  J R Smythies; R D Alarcon; D Morere; J A Monti; M Steele; L C Tolbert; W G Walter-Ryan
Journal:  Biol Psychiatry       Date:  1986-12       Impact factor: 13.382

5.  Tracer kinetic evidence for abnormal methyl metabolism in schizophrenia.

Authors:  T Sargent; N Kusubov; S E Taylor; T F Budinger
Journal:  Biol Psychiatry       Date:  1992-12-15       Impact factor: 13.382

6.  Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects.

Authors:  A B Guttormsen; J Schneede; T Fiskerstrand; P M Ueland; H M Refsum
Journal:  J Nutr       Date:  1994-10       Impact factor: 4.798

Review 7.  Role of excitotoxins in developmental neuropathology.

Authors:  J W Olney
Journal:  APMIS Suppl       Date:  1993

8.  Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry.

Authors:  S P Stabler; P D Marcell; E R Podell; R H Allen
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

9.  Homocysteinemia and schizophrenia as a case of methylation deficiency.

Authors:  B Regland; B V Johansson; C G Gottfries
Journal:  J Neural Transm Gen Sect       Date:  1994

10.  Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency.

Authors:  S P Stabler; J Lindenbaum; D G Savage; R H Allen
Journal:  Blood       Date:  1993-06-15       Impact factor: 22.113
  10 in total
  13 in total

1.  Homozygous thermolabile methylenetetrahydrofolate reductase in schizophrenia-like psychosis.

Authors:  B Regland; T Germgård; C G Gottfries; B Grenfeldt; A C Koch-Schmidt
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

2.  Serum Homocysteine and Behavioral and Psychological Symptoms of Dementia: Is There Any Correlation in Alzheimer's Disease?

Authors:  Ravi M Soni; Sarvada C Tiwari; Abbas A Mahdi; Neera Kohli
Journal:  Ann Neurosci       Date:  2018-05-30

3.  The role of vitamins and minerals in psychiatry.

Authors:  Stacey Cornish; Lewis Mehl-Madrona
Journal:  Integr Med Insights       Date:  2008-09-24

4.  Serum homocysteine and folate levels in korean schizophrenic patients.

Authors:  Tae Ho Kim; Seok Woo Moon
Journal:  Psychiatry Investig       Date:  2011-01-20       Impact factor: 2.505

5.  Serum homocysteine levels are correlated with behavioral and psychological symptoms of Alzheimer's disease.

Authors:  Hyun Kim; Kang Joon Lee
Journal:  Neuropsychiatr Dis Treat       Date:  2014-10-03       Impact factor: 2.570

6.  Female specific association between NNMT gene and schizophrenia in a Han Chinese population.

Authors:  Guo-xia Wang; Yong Zhang; Zhuang-wei Lv; Mao Sun; Dan Wu; Xin-yu Chen; Yuan-ming Wu
Journal:  Int J Med Sci       Date:  2014-09-19       Impact factor: 3.738

Review 7.  Homocysteine levels in schizophrenia and affective disorders-focus on cognition.

Authors:  Ahmed A Moustafa; Doaa H Hewedi; Abeer M Eissa; Dorota Frydecka; Błażej Misiak
Journal:  Front Behav Neurosci       Date:  2014-10-06       Impact factor: 3.558

8.  Synaptic Effects of Dopamine Breakdown and Their Relation to Schizophrenia-Linked Working Memory Deficits.

Authors:  Andrew D Bolton; Martha Constantine-Paton
Journal:  Front Synaptic Neurosci       Date:  2018-06-12

Review 9.  Involvements of Hyperhomocysteinemia in Neurological Disorders.

Authors:  Marika Cordaro; Rosalba Siracusa; Roberta Fusco; Salvatore Cuzzocrea; Rosanna Di Paola; Daniela Impellizzeri
Journal:  Metabolites       Date:  2021-01-06

10.  Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia.

Authors:  Akira Nishi; Shusuke Numata; Atsushi Tajima; Makoto Kinoshita; Kumiko Kikuchi; Shinji Shimodera; Masahito Tomotake; Kazutaka Ohi; Ryota Hashimoto; Issei Imoto; Masatoshi Takeda; Tetsuro Ohmori
Journal:  Schizophr Bull       Date:  2014-02-17       Impact factor: 9.306
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