Literature DB >> 8962684

Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anesthetics in rhesus monkey brain.

K Kobayashi1, O Inoue, Y Watanabe, H Onoe, B Långström.   

Abstract

The effects of anesthesia on dopamine D2 receptor binding in the rhesus monkey brain were examined using positron emission tomography. The bindings of 11C-N-methylspiperone (NMSP) and 11C-raclopride (RAC) were measured under controlled ketamine or isoflurane anesthesia. The binding of 11C-NMSP was significantly lower in the striatum anesthetized with isoflurane than with ketamine. There was a smaller change in the binding of 11C-RAC than of 11C-NMSP. These findings suggest that changes in 11C-NMSP or 11C-RAC binding induced by anesthetics were not due solely to changes in the competition of endogenous dopamine.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8962684     DOI： 10.1007/bf01271537

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  8 in total

1.  Nomifensine-induced increase in extracellular striatal dopamine is enhanced by isoflurane anaesthesia.

Authors:  J Opacka-Juffry; R G Ahier; J E Cremer
Journal:  Synapse       Date:  1991-02       Impact factor: 2.562

2.  Endogenous dopamine lowers the dopamine D2 receptor density as measured by [3H]raclopride: implications for positron emission tomography of the human brain.

Authors:  P Seeman; H C Guan; H B Niznik
Journal:  Synapse       Date:  1989       Impact factor: 2.562

3.  A comparison of the brain uptake of N-(cyclopropyl[11C]methyl)norbuprenorphine ([11C]buprenorphine) and N-(cyclopropyl[11C]methyl)nordiprenorphine ([11C]diprenorphine) in baboon using PET.

Authors:  C Y Shiue; L Q Bai; R R Teng; C D Arnett; S L Dewey; A P Wolf; D W McPherson; J S Fowler; J Logan; M J Holland
Journal:  Int J Rad Appl Instrum B       Date:  1991

4.  Mapping muscarinic receptors in human and baboon brain using [N-11C-methyl]-benztropine.

Authors:  S L Dewey; R R MacGregor; J D Brodie; B Bendriem; P T King; N D Volkow; D J Schlyer; J S Fowler; A P Wolf; S J Gatley
Journal:  Synapse       Date:  1990       Impact factor: 2.562

5.  PET measurement of D2 and S2 receptor binding of 3-N-[( 2'-18F]fluoroethyl)spiperone in baboon brain.

Authors:  H H Coenen; K Wienhard; G Stöcklin; P Laufer; I Hebold; G Pawlik; W D Heiss
Journal:  Eur J Nucl Med       Date:  1988

6.  Difference in in vivo receptor binding between [3H]N-methylspiperone and [3H]raclopride in reserpine-treated mouse brain.

Authors:  O Inoue; K Kobayashi; H Tsukada; T Itoh; B Langstrom
Journal:  J Neural Transm Gen Sect       Date:  1991

7.  Ketamine increases the striatal N-[11C]methylspiperone binding in vivo: positron emission tomography study using conscious rhesus monkey.

Authors:  H Onoe; O Inoue; K Suzuki; H Tsukada; T Itoh; N Mataga; Y Watanabe
Journal:  Brain Res       Date:  1994-11-14       Impact factor: 3.252

8.  Effects of endogenous dopamine on kinetics of [3H]N-methylspiperone and [3H]raclopride binding in the rat brain.

Authors:  L T Young; D F Wong; S Goldman; E Minkin; C Chen; K Matsumura; U Scheffel; H N Wagner
Journal:  Synapse       Date:  1991-11       Impact factor: 2.562
  8 in total
  4 in total

1.  Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal positron emission tomography compared to behavioral assessment and autoradiography.

Authors:  Elissa M Strome; Ivan L Cepeda; Vesna Sossi; Doris J Doudet
Journal:  Mol Imaging Biol       Date:  2006 Sep-Oct       Impact factor: 3.488

2.  Cholinergic neuronal modulation alters dopamine D2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: positron emission tomography studies with microdialysis in the conscious monkey brain.

Authors:  H Tsukada; N Harada; S Nishiyama; H Ohba; T Kakiuchi
Journal:  J Neurosci       Date:  2000-09-15       Impact factor: 6.167

3.  The effect of anaesthesia on [(18)F]MK-9470 binding to the type 1 cannabinoid receptor in the rat brain.

Authors:  Cindy Casteels; Guy Bormans; Koen Van Laere
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-02-25       Impact factor: 9.236

Review 4.  Imaging the dopamine system with in vivo [11C]raclopride displacement studies: understanding the true mechanism.

Authors:  Nathalie Ginovart
Journal:  Mol Imaging Biol       Date:  2005 Jan-Feb       Impact factor: 3.488
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.