Literature DB >> 8962117

Expression of alpha v and beta 3 integrin chains on murine lymphocytes.

D J Gerber1, P Pereira, S Y Huang, C Pelletier, S Tonegawa.   

Abstract

The vitronectin receptor is a member of the integrin family of adhesion protein receptors and binds a broad spectrum of ligands, including fibronectin and fibrinogen in addition to vitronectin. We have generated four mAbs that recognize the murine alpha v beta 3 vitronectin receptor. Biochemical and expression analyses showed that two of the mAbs are specific for the alpha v chain, and two are specific for the beta 3 chain. The mAbs are effective blocking reagents and inhibited cell adhesion to vitronectin, fibrinogen, and fibronectin. Staining analysis revealed expression of alpha v and beta 3 on certain populations of murine thymocytes, splenocytes, and bone marrow cells. The expression of alpha v and beta 3 appeared to be modulated at specific stages of thymocyte development, suggesting a possible function for the alpha v beta 3 vitronectin receptor in T cell development.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8962117      PMCID： PMC26198          DOI： 10.1073/pnas.93.25.14698

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

Review 1.  New perspectives in cell adhesion: RGD and integrins.

Authors:  E Ruoslahti; M D Pierschbacher
Journal:  Science       Date:  1987-10-23       Impact factor: 47.728

2.  Arg-Gly-Asp: a versatile cell recognition signal.

Authors:  E Ruoslahti; M D Pierschbacher
Journal:  Cell       Date:  1986-02-28       Impact factor: 41.582

Review 3.  Integrins: a family of cell surface receptors.

Authors:  R O Hynes
Journal:  Cell       Date:  1987-02-27       Impact factor: 41.582

4.  Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.

Authors:  D A Cheresh; R C Spiro
Journal:  J Biol Chem       Date:  1987-12-25       Impact factor: 5.157

5.  Alteration of cell-surface proteins by viral transformation and by proteolysis.

Authors:  R O Hynes
Journal:  Proc Natl Acad Sci U S A       Date:  1973-11       Impact factor: 11.205

6.  Platelet glycoproteins IIb and IIIa: evidence for a family of immunologically and structurally related glycoproteins in mammalian cells.

Authors:  I F Charo; L A Fitzgerald; B Steiner; S C Rall; L S Bekeart; D R Phillips
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

7.  A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.

Authors:  R Pytela; M D Pierschbacher; E Ruoslahti
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

8.  cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors.

Authors:  S Suzuki; W S Argraves; R Pytela; H Arai; T Krusius; M D Pierschbacher; E Ruoslahti
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

9.  Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi.

Authors:  E E Marcantonio; R O Hynes
Journal:  J Cell Biol       Date:  1988-05       Impact factor: 10.539

10.  The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering.

Authors:  W M Isenberg; R P McEver; D R Phillips; M A Shuman; D F Bainton
Journal:  J Cell Biol       Date:  1987-06       Impact factor: 10.539
View more
  11 in total

1.  Increased expressions of integrin subunit β1, β2 and β3 in patients with cancer ------correlation analysis between risk factors of VTE and expression of core proteins.

Authors:  Yanli Song; Lemin Wang; Fan Yang; Guiyuan Li; Qianglin Duan; Zhu Gong
Journal:  Int J Clin Exp Med       Date:  2015-02-15

2.  Evidence that integrin alpha IIb beta 3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation.

Authors:  Toshihiko Oki; Koji Eto; Kumi Izawa; Yoshinori Yamanishi; Naoki Inagaki; Jon Frampton; Toshio Kitamura; Jiro Kitaura
Journal:  J Biol Chem       Date:  2009-09-15       Impact factor: 5.157

3.  Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry.

Authors:  Shuguang Bi; Patrick W Hong; Benhur Lee; Linda G Baum
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-13       Impact factor: 11.205

4.  Early diagnosis of venous thromboembolism as a clinical primary symptom of occult cancer: Core proteins of a venous thrombus.

Authors:  Siwan Wen; Qianglin Duan; Fan Yang; Guiyuan Li; Lemin Wang
Journal:  Oncol Lett       Date:  2017-05-16       Impact factor: 2.967

Review 5.  Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation.

Authors:  A O'Regan; J S Berman
Journal:  Int J Exp Pathol       Date:  2000-12       Impact factor: 1.925

6.  Endothelial cells expressing an inflammatory phenotype are lysed by superantigen-targeted cytotoxic T cells.

Authors:  K Riesbeck; A Billström; J Tordsson; T Brodin; K Kristensson; M Dohlsten
Journal:  Clin Diagn Lab Immunol       Date:  1998-09

7.  Regulatory T cell-like responses in deer mice persistently infected with Sin Nombre virus.

Authors:  Tony Schountz; Joseph Prescott; Ann C Cogswell; Lauren Oko; Katy Mirowsky-Garcia; Alejandra P Galvez; Brian Hjelle
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-17       Impact factor: 11.205

8.  Regulation of pulmonary inflammation and fibrosis through expression of integrins alphaVbeta3 and alphaVbeta5 on pulmonary T lymphocytes.

Authors:  Irina G Luzina; Nevins W Todd; Natalia Nacu; Virginia Lockatell; Jung Choi; Laura K Hummers; Sergei P Atamas
Journal:  Arthritis Rheum       Date:  2009-05

Review 9.  The origin and onset of acute venous thrombus.

Authors:  Lemin Wang; Qianglin Duan; Fan Yang; Siwan Wen
Journal:  Int J Clin Exp Med       Date:  2015-11-15

10.  Ellipsoidal Polyaspartamide Polymersomes with Enhanced Cell-Targeting Ability.

Authors:  Mei-Hsiu Lai; Jae Hyun Jeong; Ross J Devolder; Christopher Brockman; Charles Schroeder; Hyunjoon Kong
Journal:  Adv Funct Mater       Date:  2012-08-07       Impact factor: 18.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.