K E Sullivan1, C Wooten, D Goldman, M Petri. 1. Division of Allergy, Immunology, and Infectious Diseases, Children's Hospital of Philadelphia, PA 19104, USA.
Abstract
OBJECTIVE: To determine whether dysfunctional or deficient mannose-binding protein (MBP) variants are found with increased frequency in black patients with systemic lupus erythematosus (SLE) compared with controls. METHODS: Allele-specific polymerase chain reaction amplification of 4 different polymorphic sites was performed on samples from 92 black SLE patients and 86 geographically matched black controls. RESULTS: Two structural polymorphisms of MBP, associated with low serum levels of MBP, were found with significantly increased frequency in the SLE patient population compared with controls. In contrast, a promoter haplotype associated with particularly high serum levels of MBP was negatively associated with SLE. CONCLUSION: Deficiencies of MBP predispose individuals to SLE.
OBJECTIVE: To determine whether dysfunctional or deficient mannose-binding protein (MBP) variants are found with increased frequency in black patients with systemic lupus erythematosus (SLE) compared with controls. METHODS: Allele-specific polymerase chain reaction amplification of 4 different polymorphic sites was performed on samples from 92 black SLEpatients and 86 geographically matched black controls. RESULTS: Two structural polymorphisms of MBP, associated with low serum levels of MBP, were found with significantly increased frequency in the SLEpatient population compared with controls. In contrast, a promoter haplotype associated with particularly high serum levels of MBP was negatively associated with SLE. CONCLUSION:Deficiencies of MBP predispose individuals to SLE.
Authors: S Saevarsdottir; H Kristjansdottir; G Grondal; T Vikingsdottir; K Steinsson; H Valdimarsson Journal: Ann Rheum Dis Date: 2006-01-26 Impact factor: 19.103
Authors: Peter Garred; Morten A Nielsen; Jørgen A L Kurtzhals; Rajneesh Malhotra; Hans O Madsen; Bamenla Q Goka; Bartholomew D Akanmori; Robert B Sim; Lars Hviid Journal: Infect Immun Date: 2003-09 Impact factor: 3.441