Literature DB >> 8961551

Molecular cloning and characterization of a Candida albicans gene (EFB1) coding for the elongation factor EF-1 beta.

V Maneu1, A M Cervera, J P Martínez, D Gozalbo.   

Abstract

A Candida albicans gene homologous to Saccharomyces cerevisiae elongation factor 1 beta was isolated by screening a genomic DNA library using a C. albicans cDNA as a probe. This cDNA was previously obtained by immunoscreening of an expression library with polyclonal antibodies raised against candidal cell wall components. Sequence analysis of the cDNA and the whole C. albicans gene (EMBL accession number X96517) revealed an intron-interrupted open reading frame of 639 base pairs that encodes a 213 amino acid protein. Exon sequences are highly homologous (74%) to S. cerevisiae EFB1, whereas intron sequence is less conserved (34% identity), and the predicted amino acid sequence shares about 73% identity.

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Year:  1996        PMID： 8961551     DOI： 10.1111/j.1574-6968.1996.tb08571.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  8 in total

1.  Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence.

Authors:  Carol A Munro; Steven Bates; Ed T Buurman; H Bleddyn Hughes; Donna M Maccallum; Gwyneth Bertram; Abdel Atrih; Michael A J Ferguson; Judith M Bain; Alexandra Brand; Suzanne Hamilton; Caroline Westwater; Lynn M Thomson; Alistair J P Brown; Frank C Odds; Neil A R Gow
Journal:  J Biol Chem       Date:  2004-11-01       Impact factor: 5.157

2.  Detection of Candida albicans mRNA from formalin-fixed, paraffin-embedded mouse tissues by nested reverse transcription-PCR.

Authors:  David A Schofield; Caroline Westwater; Emily E Paulling; Peter J Nicholas; Edward Balish
Journal:  J Clin Microbiol       Date:  2003-02       Impact factor: 5.948

3.  Detection of Candida albicans mRNA in archival histopathology samples by reverse transcription-PCR.

Authors:  Kyle T Beggs; Ann R Holmes; Richard D Cannon; Alison M Rich
Journal:  J Clin Microbiol       Date:  2004-05       Impact factor: 5.948

4.  Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors.

Authors:  Markus Niewerth; Donika Kunze; Michael Seibold; Martin Schaller; Hans Christian Korting; Bernhard Hube
Journal:  Antimicrob Agents Chemother       Date:  2003-06       Impact factor: 5.191

5.  The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium.

Authors:  Martin Schaller; Matthias Bein; Hans C Korting; Stefan Baur; Gerald Hamm; Michel Monod; Sabine Beinhauer; Bernhard Hube
Journal:  Infect Immun       Date:  2003-06       Impact factor: 3.441

6.  Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs.

Authors:  Angelika Felk; Marianne Kretschmar; Antje Albrecht; Martin Schaller; Sabine Beinhauer; Thomas Nichterlein; Dominique Sanglard; Hans C Korting; Wilhelm Schäfer; Bernhard Hube
Journal:  Infect Immun       Date:  2002-07       Impact factor: 3.441

7.  A quantitative real-time RT-PCR assay for mature C. albicans biofilms.

Authors:  Zhihong Xie; Angela Thompson; Helena Kashleva; Anna Dongari-Bagtzoglou
Journal:  BMC Microbiol       Date:  2011-05-06       Impact factor: 3.605

8.  Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus.

Authors:  Alexandra Brand; Donna M MacCallum; Alistair J P Brown; Neil A R Gow; Frank C Odds
Journal:  Eukaryot Cell       Date:  2004-08
  8 in total

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