Literature DB >> 8960291

Synthesis and CNS activity of new 1-alkyl-2-aryl-7-hydroxy-5(1H)oxo-imidazo[1,2-a]pyrymidines.

D Matosiuk1, T Tkaczyński, J Stefańczyk.   

Abstract

Cyclocondensation of 1,5-disubstituted 2-aminoimidazolines with diethyl malonate in the presence of sodium methanolate leading to imidazol[1,2-alpyrimidine-5,7-dion system is presented. Prevailing of 7-hydroxy-5(1H)oxo form between three possible tautomers is discussed based on spectral data. CNS activity of nine compounds is evaluated.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8960291

Source DB:  PubMed          Journal:  Acta Pol Pharm        ISSN： 0001-6837            Impact factor:   0.330


  2 in total

1.  The pseudo-Michael reaction of 1-aryl-4,5-dihydro-1H-imidazol-2-amines with ethyl ethoxymethylenecyanoacetate.

Authors:  Agnieszka A Kaczor; Urszula Kijkowska-Murak; Kalevi Pihlaja; Jari Sinkkonen; Waldemar Wysocki; Zbigniew Karczmarzyk; Dariusz Matosiuk
Journal:  Monatsh Chem       Date:  2013-05-14       Impact factor: 1.451

2.  Synthesis, central nervous system activity, and structure-activity relationship of 1-aryl-6-benzyl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones.

Authors:  Marzena Rządkowska; Elżbieta Szacoń; Agnieszka A Kaczor; Sylwia Fidecka; Ewa Kędzierska; Dariusz Matosiuk
Journal:  Med Chem Res       Date:  2014-03-27       Impact factor: 1.965
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.