Sucralfate and Helicobacter pylori.

Sucralfate enhances the eradication rate of Helicobacter pylori when administered with antibiotics. Sucralfate acts on H. pylori through mucus gel. Whether sucralfate exerts its anti-ulcer action through the eradication of H. pylori is still controversial. As sucralfate itself is an effective, well-tolerated and cost-effective anti-ulcer agent, its mechanisms of action should be investigated further.