Signal transduction pathways modulated by the D2 subfamily of dopamine receptors.

The D2 subfamily of dopamine receptors includes D2A, D2B, D3, and D4 dopamine receptors. These receptors activate cellular effector systems, principally through pertussis toxin-sensitive G-proteins. Historically, D2-like receptors in brain tissues were recognized as the dopamine receptor subtypes that inhibit adenylyl cyclase. Recent studies, reviewed here, have shown that multiple effector systems can be activated by these receptors, and the potential involvement of these in dopaminergic neutrotransmission is discussed.