Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A simplified and efficient synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).

11 in total

1. A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis.

Authors: G P Beardsley; B A Moroson; E C Taylor; R G Moran
Journal: J Biol Chem Date: 1989-01-05 Impact factor: 5.157

Review 2. Design and synthesis of inhibitors of folate-dependent enzymes as antitumor agents.

Authors: E C Taylor
Journal: Adv Exp Med Biol Date: 1993 Impact factor: 2.622

3. Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.

Authors: E C Taylor; P J Harrington; S R Fletcher; G P Beardsley; R G Moran
Journal: J Med Chem Date: 1985-07 Impact factor: 7.446

4. Intracellular metabolism of 5,10-dideazatetrahydrofolic acid in human leukemia cell lines.

Authors: G Pizzorno; J A Sokoloski; A R Cashmore; B A Moroson; A D Cross; G P Beardsley
Journal: Mol Pharmacol Date: 1991-01 Impact factor: 4.436

5. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.

Authors: J R Piper; G S McCaleb; J A Montgomery; R L Kisliuk; Y Gaumont; J Thorndike; F M Sirotnak
Journal: J Med Chem Date: 1988-11 Impact factor: 7.446

6. Synthesis and biological properties of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid.

Authors: D H Boschelli; S Webber; J M Whiteley; A L Oronsky; S S Kerwar
Journal: Arch Biochem Biophys Date: 1988-08-15 Impact factor: 4.013

7. Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM.

Authors: G Pizzorno; B A Moroson; A R Cashmore; O Russello; J R Mayer; J Galivan; M A Bunni; D G Priest; G P Beardsley
Journal: Cancer Res Date: 1995-02-01 Impact factor: 12.701

8. Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs.

Authors: L L Habeck; L G Mendelsohn; C Shih; E C Taylor; P D Colman; L S Gossett; T A Leitner; R M Schultz; S L Andis; R G Moran
Journal: Mol Pharmacol Date: 1995-08 Impact factor: 4.436

9. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.

Authors: G R Westerhof; J H Schornagel; I Kathmann; A L Jackman; A Rosowsky; R A Forsch; J B Hynes; F T Boyle; G J Peters; H M Pinedo
Journal: Mol Pharmacol Date: 1995-09 Impact factor: 4.436

10. Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase.

Authors: S W Baldwin; A Tse; L S Gossett; E C Taylor; A Rosowsky; C Shih; R G Moran
Journal: Biochemistry Date: 1991-02-19 Impact factor: 3.162

2 in total

1. Synthesis of (6R)- and (6S)-5,10-dideazatetrahydrofolate oligo-gamma-glutamates: kinetics of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase.

Authors: John W Tomsho; John J McGuire; James K Coward
Journal: Org Biomol Chem Date: 2005-08-15 Impact factor: 3.876

Review 2. Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities.

Authors: Igor S Kovalev; Grigory V Zyryanov; Sougata Santra; Adinath Majee; Mikhail V Varaksin; Valery N Charushin
Journal: Molecules Date: 2022-09-22 Impact factor: 4.927

2 in total