Literature DB >> 8958182

Antitumor diarylsulfonylureas: novel agents with unfulfilled promise.

P J Houghton1, J A Houghton.   

Abstract

Diarylsulfonylureas represent a class of antitumor agent with significant therapeutic efficacy against rodent and human models of cancer. Despite the exciting preclinical activity of sulofenur, the prototypic agent, clinical activity was poor. Here we review the activity of sulofenur and a second generation diarylsulfonylurea, LY295501 N-[5-(2, 3-dihydrobenzofuryl) sulfonyl]-N'-(3,4-dichlorophenyl)urea, against colon tumor xenografts, and some of the cellular pharmacology of this class of antitumor agents.

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Year:  1996        PMID： 8958182     DOI： 10.1007/bf00194530

Source DB:  PubMed          Journal:  Invest New Drugs        ISSN： 0167-6997            Impact factor:   3.850


  24 in total

1.  Novel agents effective against solid tumors: the diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships.

Authors:  J J Howbert; C S Grossman; T A Crowell; B J Rieder; R W Harper; K E Kramer; E V Tao; J Aikins; G A Poore; S M Rinzel
Journal:  J Med Chem       Date:  1990-09       Impact factor: 7.446

2.  Evaluation of N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)-urea against xenografts of pediatric rhabdomyosarcoma.

Authors:  P J Houghton; J A Houghton; L Myers; P Cheshire; J J Howbert; G B Grindey
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

3.  Diarylsulfonylureas and radiotherapy. I. In vitro studies with N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)-urea (Sulofenur).

Authors:  S Rockwell; G B Grindey
Journal:  Cancer Commun       Date:  1991-04

4.  Effects of diarylsulfonylurea antitumor agents on the function of mitochondria isolated from rat liver and GC3/c1 cells.

Authors:  G F Rush; S Rinzel; G Boder; R A Heim; J E Toth; G D Ponsler
Journal:  Biochem Pharmacol       Date:  1992-12-15       Impact factor: 5.858

5.  Studies on the cellular pharmacology of N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)-urea.

Authors:  P J Houghton; F C Bailey; G S Germain; G B Grindey; J J Howbert; J A Houghton
Journal:  Biochem Pharmacol       Date:  1990-04-01       Impact factor: 5.858

6.  Phase I clinical study of N-[(4-chlorophenyl)amino]carbonyl-2,3-dihydro-1H-indene-5-sulfonamide (LY186641).

Authors:  J D Hainsworth; K R Hande; W G Satterlee; J Kuttesch; D H Johnson; G Grindey; L E Jackson; F A Greco
Journal:  Cancer Res       Date:  1989-09-15       Impact factor: 12.701

7.  Cross-resistance to antitumor diarylsulfonylureas and collateral sensitivity to mitochondrial toxins in a human cell line selected for resistance to the antitumor agent N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)urea.

Authors:  J Sosinski; J H Thakar; G S Germain; P Dias; F C Harwood; J F Kuttesch; P J Houghton
Journal:  Mol Pharmacol       Date:  1994-05       Impact factor: 4.436

8.  Separation of resistance to antitumor diarylsulfonylurea agents from collateral sensitivity to mitochondrial toxins.

Authors:  L L Shu; P J Houghton
Journal:  Mol Pharmacol       Date:  1996-04       Impact factor: 4.436

9.  Efficacy of sulofenur and a second generation diarylsulfonylurea, N-[5-(2,3-dihydrobenzofuryl)sulfonyl]-N'-(3,4-dichlorophenyl)urea (LY295501), against colon adenocarcinoma xenografts.

Authors:  P J Houghton; P J Cheshire; L Myers; L Lutz; J Toth; G B Grindey; J A Houghton
Journal:  Anticancer Drugs       Date:  1995-04       Impact factor: 2.248

10.  Characterization of the intracellular distribution and binding in human adenocarcinoma cells of N-(4-azidophenylsulfonyl)-N'-(4-chlorophenyl)urea (LY219703), a photoaffinity analogue of the antitumor diarylsulfonylurea sulofenur.

Authors:  P J Houghton; J Sosinski; J H Thakar; G B Boder; G B Grindey
Journal:  Biochem Pharmacol       Date:  1995-03-01       Impact factor: 5.858
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  2 in total

Review 1.  Effects of sulfonylureas on tumor growth: a review of the literature.

Authors:  Giulia Pasello; Loredana Urso; Pierfranco Conte; Adolfo Favaretto
Journal:  Oncologist       Date:  2013-09-16

Review 2.  Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation.

Authors:  Agnieszka Potęga
Journal:  Molecules       Date:  2022-08-17       Impact factor: 4.927
  2 in total

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