Literature DB >> 8957550

Activated tissue renin-angiotensin systems add to the progression of heart failure.

Y M Pinto1, H Buikema, W H van Gilst, K I Lie.   

Abstract

In this paper, we review the hypothesis that activated tissue renin-angiotensin systems play a detrimental role in heart failure. The main arguments for this idea are discussed: a) tissue renin-angiotensin systems behave functionally distinct from the circulating renin-angiotensin system; b) tissue renin-angiotensin systems are activated in heart failure; c) activated tissue renin-angiotensin systems induce cardiovascular dysfunction. Finally, this hypothesis predicts that optimal treatment in heart failure requires the inhibition of tissue renin-angiotensin systems. However, studies pertaining to this prediction are still lacking, particularly in human subjects.

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Year:  1996        PMID： 8957550     DOI： 10.1007/bf00795368

Source DB:  PubMed          Journal:  Basic Res Cardiol        ISSN： 0300-8428            Impact factor:   17.165


  24 in total

Review 1.  Potential role of the tissue renin-angiotensin system in the pathophysiology of congestive heart failure.

Authors:  A T Hirsch; Y M Pinto; H Schunkert; V J Dzau
Journal:  Am J Cardiol       Date:  1990-10-02       Impact factor: 2.778

2.  Extra-renal transcription of the renin genes in multiple tissues of mice and rats.

Authors:  M Ekker; D Tronik; F Rougeon
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

3.  The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure.

Authors:  M Packer
Journal:  J Am Coll Cardiol       Date:  1992-07       Impact factor: 24.094

4.  Increased angiotensin-I converting enzyme gene expression in the failing human heart. Quantification by competitive RNA polymerase chain reaction.

Authors:  R Studer; H Reinecke; B Müller; J Holtz; H Just; H Drexler
Journal:  J Clin Invest       Date:  1994-07       Impact factor: 14.808

Review 5.  Activation of the renin-angiotensin system in heart failure and hypertrophy--studies in human hearts and transgenic rats.

Authors:  M Paul; Y M Pinto; H Schunkert; D Ganten; M Böhm
Journal:  Eur Heart J       Date:  1994-12       Impact factor: 29.983

6.  Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS).

Authors: 
Journal:  N Engl J Med       Date:  1987-06-04       Impact factor: 91.245

7.  Selective activation of cardiac angiotensinogen gene expression in post-infarction ventricular remodeling in the rat.

Authors:  K Lindpaintner; W Lu; N Neidermajer; B Schieffer; H Just; D Ganten; H Drexler
Journal:  J Mol Cell Cardiol       Date:  1993-02       Impact factor: 5.000

8.  Differential gene expression of renin and angiotensinogen in the TGR(mREN-2)27 transgenic rat.

Authors:  M A Lee; M Böhm; S Kim; S Bachmann; J Bachmann; M Bader; D Ganten
Journal:  Hypertension       Date:  1995-04       Impact factor: 10.190

9.  Selective and time related activation of the cardiac renin-angiotensin system after experimental heart failure: relation to ventricular function and morphology.

Authors:  Y M Pinto; B G de Smet; W H van Gilst; E Scholtens; S Monnink; P A de Graeff; H Wesseling
Journal:  Cardiovasc Res       Date:  1993-11       Impact factor: 10.787

10.  GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico.

Authors: 
Journal:  Lancet       Date:  1994-05-07       Impact factor: 79.321
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  2 in total

Review 1.  Angiotensin II--nitric oxide interactions in the control of sympathetic outflow in heart failure.

Authors:  I H Zucker; J L Liu
Journal:  Heart Fail Rev       Date:  2000-03       Impact factor: 4.214

2.  Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats.

Authors:  Shun-Guang Wei; Yang Yu; Zhi-Hua Zhang; Robert M Weiss; Robert B Felder
Journal:  Hypertension       Date:  2008-06-23       Impact factor: 10.190
  2 in total

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