Literature DB >> 8957545

Acceleration of contraction by beta-adrenoceptor stimulation is greater in ventricular myocytes from failing than non-failing human hearts.

S E Harding1, L A Brown, F del Monte, C H Davies, P O'Gara, G Vescovo, D G Wynne, P A Poole-Wilson.   

Abstract

Myocytes from failing human ventricle contract and relax more slowly than those from non-failing. This has been suggested to result from the lowering of basal cyclic AMP level in failing myocardium, and the consequent withdrawal of a tonic lusitropic effect. We present data to support this hypothesis by demonstrating that the acceleration of contraction and relaxation by beta-adrenoceptor stimulation is greater in myocytes from failing than non-failing heart. This is despite the desensitisation of the inotropic effect of isoprenaline in the same failing cells. Following beta-adrenoceptor stimulation, speeds of contraction and relaxation are normalised in myocytes from failing heart, with final values not significantly different from non-failing.

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Year:  1996        PMID： 8957545     DOI： 10.1007/bf00795363

Source DB:  PubMed          Journal:  Basic Res Cardiol        ISSN： 0300-8428            Impact factor:   17.165


  12 in total

1.  Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations.

Authors:  H von der Leyen; U Mende; W Meyer; J Neumann; M Nose; W Schmitz; H Scholz; J Starbatty; B Stein; H Wenzlaff
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-07       Impact factor: 3.000

2.  Reduced contractile responses to forskolin and a cyclic AMP analogue in myocytes from failing human ventricle.

Authors:  S E Harding; S M Jones; G Vescovo; F Del Monte; P A Poole-Wilson
Journal:  Eur J Pharmacol       Date:  1992-11-13       Impact factor: 4.432

3.  Myocardial cyclic AMP and norepinephrine content in human heart failure.

Authors:  V Regitz-Zagrosek; R Hertrampf; C Steffen; A Hildebrandt; E Fleck
Journal:  Eur Heart J       Date:  1994-12       Impact factor: 29.983

4.  Effect of inotropic stimulation on the negative force-frequency relationship in the failing human heart.

Authors:  R H Schwinger; M Böhm; J Müller-Ehmsen; R Uhlmann; U Schmidt; A Stäblein; P Uberfuhr; E Kreuzer; B Reichart; H J Eissner
Journal:  Circulation       Date:  1993-11       Impact factor: 29.690

5.  Isolated ventricular myocytes from failing and non-failing human heart; the relation of age and clinical status of patients to isoproterenol response.

Authors:  S E Harding; S M Jones; P O'Gara; F del Monte; G Vescovo; P A Poole-Wilson
Journal:  J Mol Cell Cardiol       Date:  1992-05       Impact factor: 5.000

6.  Inotropic and lusitropic dysfunction in myocardium from patients with dilated cardiomyopathy.

Authors:  R H Schwinger; M Böhm; E Erdmann
Journal:  Am Heart J       Date:  1992-01       Impact factor: 4.749

7.  cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium.

Authors:  M Böhm; B Reiger; R H Schwinger; E Erdmann
Journal:  Cardiovasc Res       Date:  1994-11       Impact factor: 10.787

8.  Reduced contraction and altered frequency response of isolated ventricular myocytes from patients with heart failure.

Authors:  C H Davies; K Davia; J G Bennett; J R Pepper; P A Poole-Wilson; S E Harding
Journal:  Circulation       Date:  1995-11-01       Impact factor: 29.690

9.  Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

Authors:  J K Gwathmey; L Copelas; R MacKinnon; F J Schoen; M D Feldman; W Grossman; J P Morgan
Journal:  Circ Res       Date:  1987-07       Impact factor: 17.367

10.  Ca(2+)-currents and intracellular [Ca2+]i-transients in single ventricular myocytes isolated from terminally failing human myocardium.

Authors:  D J Beuckelmann; E Erdmann
Journal:  Basic Res Cardiol       Date:  1992       Impact factor: 17.165
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  4 in total

1.  beta(1)- and beta(2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart.

Authors:  M Brito-Martins; S E Harding; N N Ali
Journal:  Br J Pharmacol       Date:  2008-01-14       Impact factor: 8.739

Review 2.  Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes.

Authors:  Thomas Eschenhagen; Christine Mummery; Bjorn C Knollmann
Journal:  Cardiovasc Res       Date:  2015-01-24       Impact factor: 10.787

3.  Pharmacological Modulation of Calcium Homeostasis in Familial Dilated Cardiomyopathy: An In Vitro Analysis From an RBM20 Patient-Derived iPSC Model.

Authors:  S P Wyles; S C Hrstka; S Reyes; A Terzic; T M Olson; T J Nelson
Journal:  Clin Transl Sci       Date:  2016-04-22       Impact factor: 4.689

4.  Multiparametric Mechanistic Profiling of Inotropic Drugs in Adult Human Primary Cardiomyocytes.

Authors:  Najah Abi-Gerges; Tim Indersmitten; Ky Truong; William Nguyen; Phachareeya Ratchada; Nathalie Nguyen; Guy Page; Paul E Miller; Andre Ghetti
Journal:  Sci Rep       Date:  2020-05-06       Impact factor: 4.379
  4 in total

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