Literature DB >> 8956870

Tandem triplication and quadruplication of chromosome 21 in childhood acute lymphoblastic leukemia.

E M Baialardo1, M S Felice, J Rossi, C Barreiro, M S Gallego.   

Abstract

A 5-year-old girl with ALL was shown to have a leukemic clone characterized by a triplication and quadruplication of chromosome 21, arranged in tandem, at diagnosis and relapse, respectively. To our knowledge, this is the second report of this chromosomal anomaly in ALL, which was confirmed by in situ staining. The karyotype evolution in the leukemic clone from triplication to quadruplication at relapse emphasizes the association of chromosome 21 with hematopoietic malignancies.

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Year:  1996        PMID： 8956870     DOI： 10.1016/s0165-4608(96)00151-3

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  1 in total

1.  An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome.

Authors:  C J Harrison; A V Moorman; C Schwab; A J Carroll; E A Raetz; M Devidas; S Strehl; K Nebral; J Harbott; A Teigler-Schlegel; M Zimmerman; N Dastuge; A Baruchel; J Soulier; M-F Auclerc; A Attarbaschi; G Mann; B Stark; G Cazzaniga; L Chilton; P Vandenberghe; E Forestier; I Haltrich; S C Raimondi; M Parihar; J-P Bourquin; J Tchinda; C Haferlach; A Vora; S P Hunger; N A Heerema; O A Haas
Journal:  Leukemia       Date:  2013-10-29       Impact factor: 11.528
  1 in total

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