OBJECTIVES: To explore 2 facets of dopamine receptor sensitivity in alcoholics: (1) whether reduced sensitivity of central dopamine receptors is correlated with anxiety, depression, or novelty seeking and (2) whether this reduction is associated with poor treatment outcome. METHOD: Sixty-four alcohol-dependent patients were assessed according to their clinical outcome, sensitivity of central dopamine receptors (apomorphine-induced growth hormone secretion), mood states, and personality traits before and after detoxification. RESULTS: Patients with poor treatment outcome displayed a blunted growth hormone response before, but not after, detoxification. Growth hormone response was not significantly correlated with novelty seeking. Relapsing patients tended to be less depressed than patients who remained abstinent during observation. CONCLUSION: This study did not support the hypothesis that reduced sensitivity of dopamine receptors is associated with anxiety, depressed mood, or high novelty seeking in alcoholism.
OBJECTIVES: To explore 2 facets of dopamine receptor sensitivity in alcoholics: (1) whether reduced sensitivity of central dopamine receptors is correlated with anxiety, depression, or novelty seeking and (2) whether this reduction is associated with poor treatment outcome. METHOD: Sixty-four alcohol-dependent patients were assessed according to their clinical outcome, sensitivity of central dopamine receptors (apomorphine-induced growth hormone secretion), mood states, and personality traits before and after detoxification. RESULTS:Patients with poor treatment outcome displayed a blunted growth hormone response before, but not after, detoxification. Growth hormone response was not significantly correlated with novelty seeking. Relapsing patients tended to be less depressed than patients who remained abstinent during observation. CONCLUSION: This study did not support the hypothesis that reduced sensitivity of dopamine receptors is associated with anxiety, depressed mood, or high novelty seeking in alcoholism.
Authors: Moritz de Greck; Alexander Supady; Rene Thiemann; Claus Tempelmann; Bernhard Bogerts; Lukas Forschner; Klaus V Ploetz; Georg Northoff Journal: Hum Brain Mapp Date: 2009-05 Impact factor: 5.038
Authors: M Sebold; G Spitta; T Gleich; T Dembler-Stamm; O Butler; K Zacharias; S Aydin; M Garbusow; M Rapp; F Schubert; R Buchert; J Gallinat; A Heinz Journal: J Neural Transm (Vienna) Date: 2019-02-12 Impact factor: 3.575
Authors: Gang Chen; Verginia C Cuzon Carlson; Jun Wang; Anne Beck; Andreas Heinz; Dorit Ron; David M Lovinger; Kari J Buck Journal: Alcohol Clin Exp Res Date: 2011-05-25 Impact factor: 3.455
Authors: Hans-Jochen Heinze; Marcus Heldmann; Jürgen Voges; Hermann Hinrichs; Josep Marco-Pallares; Jens-Max Hopf; Ulf J Müller; Imke Galazky; Volker Sturm; Bernard Bogerts; Thomas F Münte Journal: Front Hum Neurosci Date: 2009-09-02 Impact factor: 3.169