Literature DB >> 8956346

Influence of surface free energies and cohesion parameters on pharmaceutical material interaction parameters-theoretical simulations.

J Barra1, F Lescure, E Doelker.   

Abstract

PURPOSE: The aim of this study was to perform simulations of the influence of surface free energies and cohesion parameters on various interaction parameters within binary systems.
METHODS: Using predictive equations derived from surface free energies and cohesion parameters originally proposed by Wu (2, 3) and by Rowe (4), values of interfacial tension, spreading and reduced spreading coefficients, interaction parameter and strength of interaction were simulated by means of a data processor. The influence of polar and disperse fractions of the two interacting materials was also examined.
RESULTS: From the simulations, boundary conditions could be drawn: minimum interfacial tension, positive spreading coefficient, reduced spreading coefficient superior to unity, maximum value of the interaction parameter or of the strength of interaction.
CONCLUSIONS: Simulations of the various parameters will help the formulator to select proper materials, eg. an agent that will efficiently bind some powdered substrate, a film-forming agent that will properly coat given cores or a material that will enhibit high interaction with a substrate.

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Year:  1996        PMID: 8956346     DOI: 10.1023/a:1016417529382

Source DB:  PubMed          Journal:  Pharm Res        ISSN: 0724-8741            Impact factor:   4.200


  1 in total

1.  Wettability of pharmaceutical solids: estimates of solid surface polarity.

Authors:  G Zografi; S S Tam
Journal:  J Pharm Sci       Date:  1976-08       Impact factor: 3.534

  1 in total
  1 in total

1.  Can the organization of a binary mix be predicted from the surface energy, cohesion parameter and particle size of its components?

Authors:  J Barra; F Lescure; F Falson-Rieg; E Doelker
Journal:  Pharm Res       Date:  1998-11       Impact factor: 4.200

  1 in total

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