Literature DB >> 895418

Effect of tibric acid on hepatic cholesterol synthesis in rats.

M N Cayen, J Dubuc, D Dvornik.   

Abstract

Male albino rats were administered various oral doses of tibric acid daily for 1 week. Serum cholesterol and triglyceride levels were reduced, but total liver content of cholesterol, phospholipids, and triglycerides was increased. Tibric acid treatment suppressed the incorporation of both [14C] acetate and [3H] mevalonate into cholesterol by liver homogenates.

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Year:  1977        PMID： 895418     DOI： 10.1007/bf02533766

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  10 in total

1.  Nitrogen determination by a continuous digestion and analysis system.

Authors:  A FERRARI
Journal:  Ann N Y Acad Sci       Date:  1960-07-22       Impact factor: 5.691

2.  A new method for the direct determination of serum cholesterol.

Authors:  A ZLATKIS; B ZAK; A J BOYLE
Journal:  J Lab Clin Med       Date:  1953-03

3.  Dose-response to tibric acid: a new hypolipidemic drug in type IV hyperlipoproteinemia.

Authors:  P Bielmann; D Brun; S Moorjani; C Gagné; P Lupien; L Tétreault
Journal:  Clin Pharmacol Ther       Date:  1975-05       Impact factor: 6.875

4.  Clinical evaluation of tibric acid (CP 18,524) a new hypolipidemic agent.

Authors:  C R Sirtori; S Zoppi; B Quarisa; E Agradi
Journal:  Pharmacol Res Commun       Date:  1974-10

5.  [Clinical trial of tibric acid, a new hypolipidemic agent].

Authors:  G Noseda; C R Sirtori
Journal:  Schweiz Med Wochenschr       Date:  1974-12-21

6.  Effect of glucose and fructose administration on lipid metabolism in the rat.

Authors:  H Bar-On; Y Stein
Journal:  J Nutr       Date:  1968-01       Impact factor: 4.798

7.  Agents affecting lipid metabolism. XXXI. Properties of an inhibitor of cholesterol synthesis present in rabbit liver mitochondria.

Authors:  M N Cayen; D Dvornik
Journal:  Can J Biochem       Date:  1968-02

8.  Effect of fructose on rat lipids.

Authors:  P Hill
Journal:  Lipids       Date:  1970-07       Impact factor: 1.880

9.  A semi-automated determination of phospholipids.

Authors:  M Kraml
Journal:  Clin Chim Acta       Date:  1966-04       Impact factor: 3.786

10.  Influence of four agents (tibric acid, DH 990, oxandrolone and Sch 9122) on aspects of lipid metabolism in rats).

Authors:  D Kritchevsky; S A Tepper; J A Story
Journal:  Arzneimittelforschung       Date:  1976
  10 in total

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