Literature DB >> 8953790

Analysis of combinatorial libraries using electrospray Fourier transform ion cyclotron resonance mass spectrometry.

J P Nawrocki1, M Wigger, C H Watson, T W Hayes, M W Senko, S A Benner, J R Eyler.   

Abstract

Electrospray ionization coupled with Fourier transform ion cyclotron resonance (FTICR) mass spectrometry has been used to provide information about complete combinatorial libraries of small peptides containing 10(3)-10(4) components. The fidelity of attempted synthesis steps can be ascertained rapidly, and, when the extremely high resolution FTICR mass spectra are combined with appropriate computer simulation, both diversity and degeneracy of the libraries as synthesized can be assessed.

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Year:  1996        PMID： 8953790     DOI： 10.1002/(SICI)1097-0231(199611)10:14<1860::AID-RCM770>3.0.CO;2-#

Source DB:  PubMed          Journal:  Rapid Commun Mass Spectrom        ISSN： 0951-4198            Impact factor:   2.419


  6 in total

1.  Determining synthetic failures in combinatorial libraries by hybrid gas-phase separation methods.

Authors:  C A Srebalus; J Li; W S Marshall; D E Clemmer
Journal:  J Am Soc Mass Spectrom       Date:  2000-04       Impact factor: 3.109

2.  Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries.

Authors:  M T Cancilla; M D Leavell; J Chow; J A Leary
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

3.  Fourier transform-ion cyclotron resonance mass spectrometric resolution, identification, and screening of non-covalent complexes of Hck Src homology 2 domain receptor and ligands from a 324-member peptide combinatorial library.

Authors:  Maria Wigger; John R Eyler; Steven A Benner; Weiqun Li; Alan G Marshall
Journal:  J Am Soc Mass Spectrom       Date:  2002-10       Impact factor: 3.109

4.  Identification of novel histone post-translational modifications by peptide mass fingerprinting.

Authors:  Liwen Zhang; Ericka E Eugeni; Mark R Parthun; Michael A Freitas
Journal:  Chromosoma       Date:  2003-07-09       Impact factor: 4.316

5.  Limitations of the coupling of amino acid mixtures for the preparation of equimolar peptide libraries.

Authors:  J A Boutin; I Gesson; J M Henlin; S Bertin; P H Lambert; J P Volland; J L Fauchère
Journal:  Mol Divers       Date:  1997       Impact factor: 2.943

6.  Development of LC-IMS-CID-TOFMS techniques: analysis of a 256 component tetrapeptide combinatorial library.

Authors:  Amy E Hilderbrand; Sunnie Myung; Catherine A Srebalus Barnes; David E Clemmer
Journal:  J Am Soc Mass Spectrom       Date:  2003-12       Impact factor: 3.109
  6 in total

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