| Literature DB >> 8953669 |
A Koshy1, S Grover, K C Hyams, M A Shabrawy, A Pacsa, B al-Nakib, S A Zaidi, A A al-Anezi, S al-Mufti, J Burans, M Carl, A L Richards.
Abstract
53 adult patients with acute hepatitis caused by hepatitis E virus were identified by the presence of IgM antibody to hepatitis E virus, and followed for 12 months to evaluate the kinetics of anti-HEV antibodies. All but 1 female Kuwaiti patient were expatriate workers from the Indian subcontinent, temporarily working in Kuwait. Follow-up samples obtained at 1, 3, 6 and 12 months were evaluated for IgM and IgG antibodies to hepatitis E virus. IgM-class antibodies to hepatitis E virus were detectable in 12/27 (44%) patients at 1 months, in 0/26 at 3 months, in 0/8 at 6 months and 0/6 at 12 months. IgG antibodies to hepatitis E virus were detectable in 46/47 (98%) at onset, 26/27 (96%) at 1 month, in 26/29 (90%) at 3 months, 16/16 (100%) at 6 months and 8/8 (100%) at 12 months of follow-up. This study suggests that IgM antibodies to hepatitis E virus decline rapidly after an acute infection but IgG antibodies to hepatitis E virus persists for at least 1 year in many patients.Entities:
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Year: 1996 PMID： 8953669 DOI： 10.3109/00365549609037935
Source DB: PubMed Journal: Scand J Infect Dis ISSN： 0036-5548