Literature DB >> 8953432

Flavones with antibacterial activity against cariogenic bacteria.

M Sato1, S Fujiwara, H Tsuchiya, T Fujii, M Iinuma, H Tosa, Y Ohkawa.   

Abstract

Methanolic extracts obtained from 13 plants were studied for their antibacterial activity against cariogenic bacteria. Among them, the extract from Artocarpus heterophyllus showed the most intensive activity. Serial chromatographic purifications offered two active compounds which were identified as 6-(3-methyl-1-butenyl)-5,2',4'-trihydroxy-3-isoprenyl-7-methoxy flavone and 5,7,2',4'-tetrahydroxy-6-isoprenylflavone. Both isolates completely inhibited the growth of primary cariogenic bacteria at 3.13-12.5 micrograms/ml. They also exhibited the growth inhibitory effects on plaque-forming streptococci. These phytochemical isoprenylflavones would be potent compounds for the prevention of dental caries.

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Year:  1996        PMID： 8953432     DOI： 10.1016/s0378-8741(96)01464-x

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  17 in total

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9.  Antiproliferative activity of xanthones isolated from Artocarpus obtusus.

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10.  Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases.

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