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Literature DB >> 8947459

Functional characterization by heterologous expression of a novel cloned tachykinin peptide receptor.

L F Donaldson¹, C A Haskell, M R Hanley.

Abstract

An orphan receptor resembling the neurokinin 3 tachykinin receptor (NK3), initially claimed to be an atypical opioid receptor, is shown herein to respond potently to the physiological NK3 receptor ligand, neurokinin B. This 'NK4' receptor did not give functional responses in Xenopus oocytes to opioid agonists. However, NK4 receptor activation was inhibited by nanomolar concentrations of dynorphin. The NK4 receptor is therefore a tachykinin receptor which is functionally antagonized by an endogenous opioid peptide.

Entities: Gene Species

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Year: 1996 PMID： 8947459 PMCID： PMC1217889 DOI： 10.1042/bj3200001

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

14 in total

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5 in total

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2. Molecular and pharmacological characterization of a functional tachykinin NK3 receptor cloned from the rabbit iris sphincter muscle.

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