Literature DB >> 8945781

Antiandrogen. IV. C-17 spiro 2-oxasteroids.

N Koizumi1, S Takegawa, M Mieda, K Shibata.   

Abstract

The preparation of 6- and/or 7-substituted 3-oxo-2-oxasteroids having a spirotetrahydrofuran ring at the 17-position is described. These compounds showed high antiandrogenic potency in the castrated male rat.

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Year:  1996        PMID： 8945781     DOI： 10.1248/cpb.44.2162

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  2 in total

1.  Nitrenium ion azaspirocyclization-spirodienone cleavage: a new synthetic strategy for the stereocontrolled preparation of highly substituted lactams and N-hydroxy lactams.

Authors:  Duncan J Wardrop; Matthew S Burge
Journal:  J Org Chem       Date:  2005-12-09       Impact factor: 4.354

2.  Synthesis, characterization and biological evaluation of some novel P-heterocyclic androst-4-ene derivatives.

Authors:  Natalija M Krstić; Vladimir D Pavlović; Irena T Novaković; Ivana Z Matić; Dušan M Sladić
Journal:  Mol Divers       Date:  2013-06-09       Impact factor: 2.943
  2 in total

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