Literature DB >> 8945595

Production of human tumor necrosis factor alpha, interleukin-6, and interleukin-10 is induced by lactic acid bacteria.

M Miettinen1, J Vuopio-Varkila, K Varkila.   

Abstract

To investigate the role of cytokines in interactions between lactic acid bacteria and the immune system, we measured production of tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-10 from human peripheral blood mononuclear cells after stimulation with live or glutaraldehyde-fixed bacteria. Production of tumor necrosis factor alpha, IL-6, and, in some cases, IL-10 was induced in amounts even greater than those obtained with lipopolysaccharide as a stimulant. Our results suggest that lactic acid bacteria can stimulate nonspecific immunity.

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Year:  1996        PMID: 8945595      PMCID: PMC174537          DOI: 10.1128/iai.64.12.5403-5405.1996

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  27 in total

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Journal:  Infect Immun       Date:  1994-07       Impact factor: 3.441

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  79 in total

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8.  Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18, and gamma interferon production in human peripheral blood mononuclear cells.

Authors:  M Miettinen; S Matikainen; J Vuopio-Varkila; J Pirhonen; K Varkila; M Kurimoto; I Julkunen
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