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Literature DB >> 8943969

Intraduodenal lipid does not inhibit acid secretion in OLETF rats not expressing CCK-A receptor gene.

Abstract

Gastric acid secretion in response to pylorus-ligation and duodenal fat feeding in Otsuka Long-Evans Tokushima Fatty (OLETF) rats without cholecystokinin-A receptor was examined. Acidity of gastric juice obtained from pylorus-ligated OLETF rats was significantly lower than that of control LETO rats. Gastric acid secretion in response to bethanechol, pentagastrin, or atropine was maintained in both OLETF and LETO rats. Intraduodenal lipid injection strongly inhibited gastric acid secretion in control LETO rats. In contrast, administration of lipid into the duodenum failed to inhibit acid secretion in OLETF rats. These results suggest that basal gastric acid secretion may be impaired in OLETF rats and that the cholecystokinin-A receptor is involved in lipid-induced acid inhibition.

Entities: Chemical Disease Gene Species

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Year: 1996 PMID： 8943969 DOI： 10.1007/bf02071397

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

24 in total

1. Neural and hormonal mechanisms mediate the enterogastric reflex: a study in intestinal transplants in rats.

Authors: S L Orloff; N W Bunnett; H Wong; J H Walsh; H T Debas
Journal: Gastroenterology Date: 1991-09 Impact factor: 22.682

2. Cholecystokinin receptor antagonist MK-329 blocks intestinal fat-induced inhibition of meal-stimulated gastric acid secretion.

Authors: K C Lloyd; V Maxwell; T O Kovacs; J Miller; J H Walsh
Journal: Gastroenterology Date: 1992-01 Impact factor: 22.682

3. Apolipoprotein A-IV acts in the brain to inhibit gastric emptying in the rat.

Authors: T Okumura; K Fukagawa; P Tso; I L Taylor; T N Pappas
Journal: Am J Physiol Date: 1996-01

4. Effect of secretin and cholecystokinin on pentagastrin-stimulated gastric secretion in man.

Authors: A M Brooks; M I Grossman
Journal: Gastroenterology Date: 1970-07 Impact factor: 22.682

5. Effects of monoclonal antibodies to somatostatin on somatostatin-induced and intestinal fat-induced inhibition of gastric acid secretion in the rat.

Authors: A M Seal; R M Meloche; Y Q Liu; A M Buchan; J C Brown
Journal: Gastroenterology Date: 1987-05 Impact factor: 22.682

6. Lack of satiety effect of cholecystokinin (CCK) in a new rat model not expressing the CCK-A receptor gene.

Authors: K Miyasaka; S Kanai; M Ohta; T Kawanami; A Kono; A Funakoshi
Journal: Neurosci Lett Date: 1994-10-24 Impact factor: 3.046

7. Mechanism of action of intracisternal apolipoprotein A-IV in inhibiting gastric acid secretion in rats.

Authors: T Okumura; K Fukagawa; P Tso; I L Taylor; T N Pappas
Journal: Gastroenterology Date: 1995-11 Impact factor: 22.682

8. Regulation of gastric emptying in humans by cholecystokinin.

Authors: R A Liddle; E T Morita; C K Conrad; J A Williams
Journal: J Clin Invest Date: 1986-03 Impact factor: 14.808

9. Fat inhibition of gastric acid secretion in man and plasma concentrations of neurotensin-like immunoreactivity.

Authors: B Kihl; A Rökaeus; S Rosell; L Olbe
Journal: Scand J Gastroenterol Date: 1981 Impact factor: 2.423

10. Little or no expression of the cholecystokinin-A receptor gene in the pancreas of diabetic rats (Otsuka Long-Evans Tokushima Fatty = OLETF rats).

Authors: A Funakoshi; K Miyasaka; A Jimi; T Kawanai; Y Takata; A Kono
Journal: Biochem Biophys Res Commun Date: 1994-03-15 Impact factor: 3.575

3 in total