BACKGROUND: Interleukin-6 (IL-6), interleukin-8 (IL-8), and adhesion molecules have been implicated as mediators in neutrophil (PMN) and endothelial cell (EC) interactions leading to postinjury multiple organ failure (MOF). Our hypothesis was that circulating levels of IL-6, IL-8, and soluble intercellular adhesion molecule-1 (sICAM-1) would discriminate patients at risk for postinjury MOF. METHODS: Serial plasma levels of IL-6, IL-8, and sICAM-1 were measured in 27 high-risk trauma patients. RESULTS: The IL-6 and IL-8 levels were significantly elevated in MOF patients compared with non-MOF patients at 12 and 36 hours postinjury. The IL-6 level was also elevated at 84 and 132 hours, and IL-8 at 84 hours. The sICAM-1 level did not become elevated in MOF patients until 132 hours postinjury. CONCLUSION: Interleukin-6 and IL-8 are elevated early after trauma and discriminate patients who will develop MOF. Late elevation of sICAM-1 likely results from PMN cytotoxicity leading to EC injury or inflammation.
BACKGROUND:Interleukin-6 (IL-6), interleukin-8 (IL-8), and adhesion molecules have been implicated as mediators in neutrophil (PMN) and endothelial cell (EC) interactions leading to postinjury multiple organ failure (MOF). Our hypothesis was that circulating levels of IL-6, IL-8, and soluble intercellular adhesion molecule-1 (sICAM-1) would discriminate patients at risk for postinjury MOF. METHODS: Serial plasma levels of IL-6, IL-8, and sICAM-1 were measured in 27 high-risk traumapatients. RESULTS: The IL-6 and IL-8 levels were significantly elevated in MOF patients compared with non-MOF patients at 12 and 36 hours postinjury. The IL-6 level was also elevated at 84 and 132 hours, and IL-8 at 84 hours. The sICAM-1 level did not become elevated in MOF patients until 132 hours postinjury. CONCLUSION:Interleukin-6 and IL-8 are elevated early after trauma and discriminate patients who will develop MOF. Late elevation of sICAM-1 likely results from PMN cytotoxicity leading to EC injury or inflammation.
Authors: Steven L Shein; David K Shellington; Jennifer L Exo; Travis C Jackson; Stephen R Wisniewski; Edwin K Jackson; Vincent A Vagni; Hülya Bayır; Robert S B Clark; C Edward Dixon; Keri L Janesko-Feldman; Patrick M Kochanek Journal: J Neurotrauma Date: 2014-08-15 Impact factor: 5.269
Authors: Katherine A Barsness; Denis D Bensard; David A Partrick; Casey M Calkins; Richard J Hendrickson; Anirban Banerjee; Robert C McIntyre Journal: Pediatr Surg Int Date: 2004-04-21 Impact factor: 1.827
Authors: Michael Frink; Martijn van Griensven; Philipp Kobbe; Thomas Brin; Christian Zeckey; Bernhard Vaske; Christian Krettek; Frank Hildebrand Journal: Scand J Trauma Resusc Emerg Med Date: 2009-09-27 Impact factor: 2.953