OBJECTIVE: The authors tested whether early prenatal exposure to famine was associated with schizophrenia spectrum personality disorder in addition to being associated with schizophrenia per se as shown in a previous study. METHOD: The risk of schizoid personality disorder, as defined by ICD-6 to ICD-9, in men at age 18 years was compared in birth cohorts that were conceived at the height of the Dutch Hunger Winter famine and in unexposed birth cohorts of 1944-1946 in the famine region of Holland. RESULTS: The exposed cohort had a significantly greater risk (relative risk = 2.01) of schizoid personality disorder. CONCLUSIONS: Prenatal nutritional deficiency was associated with a greater risk of schizoid personality disorder in men at age 18 years.
OBJECTIVE: The authors tested whether early prenatal exposure to famine was associated with schizophrenia spectrum personality disorder in addition to being associated with schizophrenia per se as shown in a previous study. METHOD: The risk of schizoid personality disorder, as defined by ICD-6 to ICD-9, in men at age 18 years was compared in birth cohorts that were conceived at the height of the Dutch Hunger Winter famine and in unexposed birth cohorts of 1944-1946 in the famine region of Holland. RESULTS: The exposed cohort had a significantly greater risk (relative risk = 2.01) of schizoid personality disorder. CONCLUSIONS: Prenatal nutritional deficiency was associated with a greater risk of schizoid personality disorder in men at age 18 years.
Authors: Janina R Galler; Cyralene P Bryce; Miriam L Zichlin; Deborah P Waber; Natalie Exner; Garrett M Fitzmaurice; Paul T Costa Journal: J Child Psychol Psychiatry Date: 2013-03-12 Impact factor: 8.982
Authors: Abraham A Palmer; Alan S Brown; Debbra Keegan; Lara DeSanti Siska; Ezra Susser; John Rotrosen; Pamela D Butler Journal: Brain Res Date: 2008-07-30 Impact factor: 3.252