R J Norman1, S Masters, W Hague. 1. Reproductive Medicine Unit, University of Adelaide, Queen Elizabeth Hospital, Woodville, Australia.
Abstract
OBJECTIVE: To determine whether disorders of insulin secretion are common in male and female family members of subjects with polycystic ovary syndrome (PCOS). DESIGN: Family study of siblings and parents of PCOS subjects (five families). All proband cases met the criteria of polycystic ovaries (PCO) by ultrasound (US) and hyperandrogenism. SETTING: University Reproductive Medicine Unit. PATIENT(S): Family members of PCOS subjects. INTERVENTION(S): Oral glucose tolerance testing (OGTT), insulin, and lipids were measured. Clinical examination including assessment of premature baldness in men and US of ovaries in female members. MAIN OUTCOME MEASURE(S): Insulin, lipids, and clinical parameters. RESULT(S): Hyperinsulinemia (69%) and hypertriglyceridemia (56%) was common in family members as were PCO in 79% of 24 females and premature baldness in men in 88% of eight subjects. CONCLUSION(S): Hyperinsulinemia is a potential metabolic and genetic marker for subjects who may be carriers of a familial tendency for PCO.
OBJECTIVE: To determine whether disorders of insulin secretion are common in male and female family members of subjects with polycystic ovary syndrome (PCOS). DESIGN: Family study of siblings and parents of PCOS subjects (five families). All proband cases met the criteria of polycystic ovaries (PCO) by ultrasound (US) and hyperandrogenism. SETTING: University Reproductive Medicine Unit. PATIENT(S): Family members of PCOS subjects. INTERVENTION(S): Oral glucose tolerance testing (OGTT), insulin, and lipids were measured. Clinical examination including assessment of premature baldness in men and US of ovaries in female members. MAIN OUTCOME MEASURE(S): Insulin, lipids, and clinical parameters. RESULT(S): Hyperinsulinemia (69%) and hypertriglyceridemia (56%) was common in family members as were PCO in 79% of 24 females and premature baldness in men in 88% of eight subjects. CONCLUSION(S): Hyperinsulinemia is a potential metabolic and genetic marker for subjects who may be carriers of a familial tendency for PCO.
Authors: E Diamanti-Kandarakis; K Alexandraki; A Bergiele; H Kandarakis; G Mastorakos; A Aessopos Journal: J Endocrinol Invest Date: 2004-11 Impact factor: 4.256
Authors: Richard S Legro; Rhonda Bentley-Lewis; Deborah Driscoll; Steve C Wang; Andrea Dunaif Journal: J Clin Endocrinol Metab Date: 2002-05 Impact factor: 5.958