Literature DB >> 8940021

Subunit stoichiometry of a heteromultimeric G protein-coupled inward-rectifier K+ channel.

S K Silverman1, H A Lester, D A Dougherty.   

Abstract

We investigated the stoichiometry of the heteromultimeric G protein-coupled inward-recitfier K+ channel (GIRK) formed from GIRK1 and GIRK4 subunits. Multimeric GIRK constructs with several concatenated channel subunits were expressed in Xenopus oocytes. Coexpression of various trimeric constructs with different monomers clearly showed that the functional channel has stoichiometry (GIRK1)2(GIRK4)2. Efforts to establish a preferred arrangement of subunits around the channel pore suggest that more than one arrangement may be viable.

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Year:  1996        PMID： 8940021     DOI： 10.1074/jbc.271.48.30524

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  22 in total

1.  The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype.

Authors:  P Hou; S Yan; W Tang; D J Nelson
Journal:  J Neurosci       Date:  1999-10-01       Impact factor: 6.167

2.  Single channel analysis of the regulation of GIRK1/GIRK4 channels by protein phosphorylation.

Authors:  Carmen Müllner; Daniel Yakubovich; Carmen W Dessauer; Dieter Platzer; Wolfgang Schreibmayer
Journal:  Biophys J       Date:  2003-02       Impact factor: 4.033

3.  Graded contribution of the Gbeta gamma binding domains to GIRK channel activation.

Authors:  Rona Sadja; Noga Alagem; Eitan Reuveny
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-17       Impact factor: 11.205

4.  Fluorescence measurements reveal stoichiometry of K+ channels formed by modulatory and delayed rectifier alpha-subunits.

Authors:  Daniel Kerschensteiner; Florentina Soto; Martin Stocker
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-12       Impact factor: 11.205

5.  Functional characterization of a small conductance GIRK channel in rat atrial cells.

Authors:  Emil N Nikolov; Tatyana T Ivanova-Nikolova
Journal:  Biophys J       Date:  2004-11       Impact factor: 4.033

6.  Subunit stoichiometry of heterologously expressed G-protein activated inwardly rectifying potassium channels analysed by fluorescence intensity ratio measurement.

Authors:  E Grasser; B Steinecker; H Ahammer; W Schreibmayer
Journal:  Pflugers Arch       Date:  2007-10-17       Impact factor: 3.657

7.  G alpha(i) and G betagamma jointly regulate the conformations of a G betagamma effector, the neuronal G protein-activated K+ channel (GIRK).

Authors:  Shai Berlin; Tal Keren-Raifman; Ruth Castel; Moran Rubinstein; Carmen W Dessauer; Tatiana Ivanina; Nathan Dascal
Journal:  J Biol Chem       Date:  2009-12-16       Impact factor: 5.157

8.  A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation.

Authors:  S K Silverman; P Kofuji; D A Dougherty; N Davidson; H A Lester
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-24       Impact factor: 11.205

9.  Asymmetrical contributions of subunit pore regions to ion selectivity in an inward rectifier K+ channel.

Authors:  S K Silverman; H A Lester; D A Dougherty
Journal:  Biophys J       Date:  1998-09       Impact factor: 4.033

10.  Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors.

Authors:  Paul J Groot-Kormelink; Steven D Broadbent; James P Boorman; Lucia G Sivilotti
Journal:  J Gen Physiol       Date:  2004-05-17       Impact factor: 4.086
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