Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Roles of the JAK-STAT system in signal transduction via cytokine receptors.

Literature DB >> 8939729

Roles of the JAK-STAT system in signal transduction via cytokine receptors.

Abstract

JAK-STAT signaling pathways are known to play an essential role in the specific activation of interferon-inducible genes. Many cytokines interacting with the cytokine receptor superfamily also appear to activate these pathways. Recent evidence indicates that JAKs play an essential role(s) in cytokine receptor signaling, including both specific pathways linked to STATs and general pathways regulating cell growth and functions.

Mesh：

Substances：

Year: 1996 PMID： 8939729 DOI： 10.1016/s0959-437x(96)80088-8

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

Keyword Cloud
Cited

11 in total

1. Distinct mechanisms of activation of Stat1 and Stat3 by platelet-derived growth factor receptor in a cell-free system.

Authors: M L Vignais; M Gilman
Journal: Mol Cell Biol Date: 1999-05 Impact factor: 4.272

2. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.

Authors: J Schwaller; J Frantsve; J Aster; I R Williams; M H Tomasson; T S Ross; P Peeters; L Van Rompaey; R A Van Etten; R Ilaria; P Marynen; D G Gilliland
Journal: EMBO J Date: 1998-09-15 Impact factor: 11.598

3. Stimulation of c-Src by prolactin is independent of Jak2.

Authors: J A Fresno Vara; M V Carretero; H Gerónimo; K Ballmer-Hofer; J Martín-Pérez
Journal: Biochem J Date: 2000-01-01 Impact factor: 3.857

4. Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock.

Authors: Jixin Zhong; Ping Yang; Kenjiro Muta; Robert Dong; Mario Marrero; Feili Gong; Cong-Yi Wang
Journal: PLoS One Date: 2010-03-09 Impact factor: 3.240

9. Murine cytomegalovirus infection of mouse macrophages stimulates early expression of suppressor of cytokine signaling (SOCS)1 and SOCS3.

Authors: Christine I Alston; Richard D Dix
Journal: PLoS One Date: 2017-02-09 Impact factor: 3.240

10. Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10.

Authors: J E Nagel; R J Smith; L Shaw; D Bertak; V D Dixit; E M Schaffer; D D Taub
Journal: BMC Immunol Date: 2004-08-05 Impact factor: 3.615

Roles of the JAK-STAT system in signal transduction via cytokine receptors.

1. Distinct mechanisms of activation of Stat1 and Stat3 by platelet-derived growth factor receptor in a cell-free system.

2. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.

3. Stimulation of c-Src by prolactin is independent of Jak2.

4. Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock.

5. Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling.

6. C/EBPalpha is critical for the neonatal acute-phase response to inflammation.

7. Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells.

8. Interleukin 2-mediated uncoupling of T cell receptor alpha/beta from CD3 signaling.

9. Murine cytomegalovirus infection of mouse macrophages stimulates early expression of suppressor of cytokine signaling (SOCS)1 and SOCS3.

10. Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10.