| Literature DB >> 8938273 |
N E Blachere1, P K Srivastava.
Abstract
Heat shock proteins (HSPs) are associated in vivo with the entire repertoire of peptides (antigenic and otherwise) generated within that cell. Immunization with such non-covalent HSP-peptide complexes is unusually efficient in eliciting cellular immune responses against the antigenic peptides associated with the HSPs. This broad and general principle is the basis for a new generation of vaccines against cancers and infectious diseases and circumvents the need for identification of the T-cell epitopes for any given cancer or infectious agent.Entities:
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Year: 1995 PMID： 8938273 DOI： 10.1016/1044-579x(95)90004-7
Source DB: PubMed Journal: Semin Cancer Biol ISSN： 1044-579X Impact factor: 15.707