Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The in-vitro anti-rickettsial activity of macrolides.

Literature DB >> 8937968

The in-vitro anti-rickettsial activity of macrolides.

A Keysary¹, A Itzhaki, E Rubinstein, C Oron, G Keren.

Abstract

The anti-rickettsial activity of azithromycin and clarithromycin was studied in Vero cells. The rate of rickettsial inhibition-growth caused by both macrolides was determined using rickettsial counts and ELISA. Both macrolides inhibited > 50% the growth of Rickettsia conorii and Rickettsia typhi at concentrations of 1.0 and 0.1 mg/L, respectively. The growth of Coxiella burnetii was inhibited to a rate of > or = 50% at the concentrations of 0.01 and 1.0 mg/L of azithromycin and clarithromycin, respectively.

Entities: Chemical Species

Mesh：

Substances：

Year: 1996 PMID： 8937968 DOI： 10.1093/jac/38.4.727

Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790

Keyword Cloud
Cited

13 in total

1. In vitro activities of telithromycin (HMR 3647) against Rickettsia rickettsii, Rickettsia conorii, Rickettsia africae, Rickettsia typhi, Rickettsia prowazekii, Coxiella burnetii, Bartonella henselae, Bartonella quintana, Bartonella bacilliformis, and Ehrlichia chaffeensis.

Authors: J M Rolain; M Maurin; A Bryskier; D Raoult
Journal: Antimicrob Agents Chemother Date: 2000-05 Impact factor: 5.191

2. Rickettsial meningitis.

Authors: Inês Salva; Rita de Sousa; Catarina Gouveia
Journal: BMJ Case Rep Date: 2014-03-10

Review 3. Antimicrobial therapies for Q fever.

Authors: Gilbert J Kersh
Journal: Expert Rev Anti Infect Ther Date: 2013-09-27 Impact factor: 5.091

10. A rapid real-time quantitative PCR assay to determine the minimal inhibitory extracellular concentration of antibiotics against an intracellular Francisella tularensis Live Vaccine Strain.

Authors: Ronit Aloni-Grinstein; Ohad Shifman; Shlomi Lazar; Ida Steinberger-Levy; Sharon Maoz; Raphael Ber
Journal: Front Microbiol Date: 2015-11-03 Impact factor: 5.640

The in-vitro anti-rickettsial activity of macrolides.

1. In vitro activities of telithromycin (HMR 3647) against Rickettsia rickettsii, Rickettsia conorii, Rickettsia africae, Rickettsia typhi, Rickettsia prowazekii, Coxiella burnetii, Bartonella henselae, Bartonella quintana, Bartonella bacilliformis, and Ehrlichia chaffeensis.

2. Rickettsial meningitis.

Review 3. Antimicrobial therapies for Q fever.

4. Azithromycin: single 1.5 g dose in the treatment of patients with atypical pneumonia syndrome--a randomized study.

5. Newer macrolides as empiric treatment for acute Q fever infection.

6. A case of acute q Fever with severe acute cholestatic hepatitis.

7. Azithromycin for acute Q fever in pregnancy.

8. In vitro susceptibilities of 27 rickettsiae to 13 antimicrobials.

9. Q fever update, Maritime Canada.

10. A rapid real-time quantitative PCR assay to determine the minimal inhibitory extracellular concentration of antibiotics against an intracellular Francisella tularensis Live Vaccine Strain.