| Literature DB >> 893794 |
D M Chauncey, H R Schelbert, S E Halpern, F Delano, M L McKegney, W L Ashburn, P L Hagan.
Abstract
Manganese, a trace metal, is known to localize in mitochondria. Because mitochondria are abundant in heart muscle, the possible utility of radioactive manganese as a myocardial imaging agent was examined in 25 rats and six dogs. Myocardial uptake of Mn-54 in rats was found to exceed that of thallium-201; myocardium-to-blood ratios averaged 306:1 versus 48:1 for Tl-201. In the dog, uptake of Mn-54 by ischemic myocardium was reduced by 17-75% compared with normal myocardium. Thus, radioactive manganese appears promising as an intravenous myocardial imaging agent, and might be useful in studying the function of myocardial mitochondria by external imaging.Entities:
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Year: 1977 PMID： 893794
Source DB: PubMed Journal: J Nucl Med ISSN： 0161-5505 Impact factor: 10.057