| Literature DB >> 893592 |
J A Timbrell, J M Wright, C M Smith.
Abstract
A method is described for the determination of isoniazid, acetylisoniazid, acetylhydrazine, diacetylhydrazine and hydrazine in urine. Isoniazid, acetylhydrazine and hydrazine are reacted in aqueous solution with p-chlorobenzaldehyde to form hydrazones. Following the addition of appropriate internal standards, these hydrazones are then extracted into an organic solvent and determined by gas chromatography using a nitrogen-sensitive detector. Acetylisoniazid and diacetylhydrazine are determined similarly after hydrolysis to isoniazid and acetylhydrazine, respectively.Entities:
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Year: 1977 PMID： 893592 DOI： 10.1016/s0021-9673(00)98007-5
Source DB: PubMed Journal: J Chromatogr