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Literature DB >> 8935817

Does eosinophilia predict clozapine induced neutropenia?

M Hummer¹, B Sperner-Unterweger, G Kemmler, M Falk, M Kurz, H Oberbauer, W W Fleischhacker.

Abstract

The atypical antipsychotic clozapine carries a high risk of inducing agranulocytosis. We attempted to investigate whether eosinophilia during clozapine treatment has predictive value for subsequent neutropenia/agranulocytosis. One hundred and seventy-seven patients were studied in a prospective naturalistic design using haloperidol as the reference compound. Clozapine was found to differ from haloperidol in respect to their influence on neutrophil granulocytes. In the clozapine group patients with eosinophilia showed a decrease in neutrophil count (less than 2000/mm3 neutrophil granulocytes) significantly more often than patients without eosinophilia.

Entities: Chemical Disease Species

Mesh：

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Year: 1996 PMID： 8935817 DOI： 10.1007/bf02245622

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

20 in total

4. Late Onset Agranulocytosis with Clozapine Associated with HLA DR4 Responding to Treatment with Granulocyte Colony-stimulating Factor: A Case Report and Review of Literature.

Authors: Aakanksha Singh; Sandeep Grover; Pankaj Malhotra; Subhash C Varma
Journal: Clin Psychopharmacol Neurosci Date: 2016-05-31 Impact factor: 2.582

4 in total

Does eosinophilia predict clozapine induced neutropenia?

1. Eosinophilia, clozapine, and pancreatitis.

2. Major histocompatibility complex associations with clozapine-induced agranulocytosis. The USA experience.

3. Eosinophilia with clozapine.

Review 4. [GM-CSF and G-CSF: cytokines in clinical application].

5. Clozapine-induced transient white blood count disorders.

6. Cytotoxic activity in serum of patients with clozapine-induced agranulocytosis.

7. High risk of eosinophilia in women treated with clozapine.

8. No direct clinical relevance of the human leucocyte antigen (HLA) system in clozapine-induced agranulocytosis.

Review 9. On the possible mechanisms and predictability of clozapine-induced agranulocytosis.

Review 10. Clozapine-associated agranulocytosis: risk and aetiology.

Review 1. Clozapine versus typical neuroleptic medication for schizophrenia.

2. Clozapine induced eosinophilia.

3. Eosinophilia induced by clozapine: a report of two cases and review of the literature.

4. Late Onset Agranulocytosis with Clozapine Associated with HLA DR4 Responding to Treatment with Granulocyte Colony-stimulating Factor: A Case Report and Review of Literature.