L L Hagemann1, P Zielinsky. 1. Instituto de Cardiologia do RS--Unidade de Pesquisa, Porto Alegre, RS.
Abstract
PURPOSE: To test the hypothesis that hypertrophic cardiomyopathy during prenatal life in diabetic pregnancies is related to fetal hyperinsulinism. METHODS: Thirty seven fetuses of diabetic mothers and 28 of non-diabetic mothers were studied by echocardiography and fetal insulin levels measured. RESULTS: Mean fetal insulin levels were 22.16 (+/- 44.25) microU/ml (3.20 to 240 microU/ml) in the group with diabetes and 6.50 (+/- 3.45) microU/ml (3.10 to 17.00 microU/ml) in the control group (p = 0.004). Ten out of 37 fetuses of the diabetic group were considered to have hypertrophic cardiomyopathy (27.02%), while none of the fetuses of the control group showed increase in septal thickness (p = 0.001). A significant association between prenatal hypertrophic cardiomyopathy and fetal hyperinsulinism was demonstrated (p = 0.013). CONCLUSION: There is an association between hypertrophic cardiomyopathy and high levels of fetal insulin.
PURPOSE: To test the hypothesis that hypertrophic cardiomyopathy during prenatal life in diabetic pregnancies is related to fetal hyperinsulinism. METHODS: Thirty seven fetuses of diabetic mothers and 28 of non-diabetic mothers were studied by echocardiography and fetal insulin levels measured. RESULTS: Mean fetal insulin levels were 22.16 (+/- 44.25) microU/ml (3.20 to 240 microU/ml) in the group with diabetes and 6.50 (+/- 3.45) microU/ml (3.10 to 17.00 microU/ml) in the control group (p = 0.004). Ten out of 37 fetuses of the diabetic group were considered to have hypertrophic cardiomyopathy (27.02%), while none of the fetuses of the control group showed increase in septal thickness (p = 0.001). A significant association between prenatal hypertrophic cardiomyopathy and fetal hyperinsulinism was demonstrated (p = 0.013). CONCLUSION: There is an association between hypertrophic cardiomyopathy and high levels of fetal insulin.
Authors: Daniel Dowling; Niamh Corrigan; Stephen Horgan; Chris J Watson; John Baugh; Paul Downey; Fionnuala M McAuliffe Journal: J Diabetes Res Date: 2014-06-26 Impact factor: 4.011