Literature DB >> 8934549

Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis.

K M Erny1, J Peli, J F Lambert, V Muller, H Diggelmann.   

Abstract

We report for the first time a relationship between the Tpl-2/cot oncogene and Mouse Mammary Tumor Virus (MMTV) associated transformation of mammary gland cells. A sub-genomic library generated from a primary mammary gland tumor yielded a novel MMTV integration site which disrupted the Tpl-2/cot proto-oncogene between exons 7 and 8. Comparison of a cell line derived from normal mammary gland (comma-D) and a cell line established from an MMTV induced mammary tumor (GR) demonstrated similar rearrangements within Tpl-2/cot for the GR cells but not in the comma-D cells. These rearrangements in the cell line were accompanied by an increase in the level of Tpl-2/cot specific mRNA. This data suggests that Tpl-2/cot expression may be important in epithelial cell transformation or tumor progression.

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Year:  1996        PMID： 8934549

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  28 in total

1.  The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity.

Authors:  Maria Luisa Gándara; Pilar López; Raquel Hernando; José G Castaño; Susana Alemany
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

2.  Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.

Authors:  Jeonghee Cho; Philip N Tsichlis
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-07       Impact factor: 11.205

3.  The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines.

Authors:  Oksana B Serebrennikova; Maria D Paraskevopoulou; Elia Aguado-Fraile; Vasiliki Taraslia; Wenying Ren; Geeta Thapa; Jatin Roper; Keyong Du; Carlo M Croce; Philip N Tsichlis
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-25       Impact factor: 11.205

Review 4.  Natural pathogens of laboratory mice, rats, and rabbits and their effects on research.

Authors:  D G Baker
Journal:  Clin Microbiol Rev       Date:  1998-04       Impact factor: 26.132

5.  Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration.

Authors:  Maria Hatziapostolou; Georgios Koukos; Christos Polytarchou; Filippos Kottakis; Oksana Serebrennikova; Athan Kuliopulos; Philip N Tsichlis
Journal:  Sci Signal       Date:  2011-08-23       Impact factor: 8.192

6.  Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.

Authors:  Aristides G Eliopoulos; Calin D Dumitru; Chun-Chi Wang; Jeonghee Cho; Philip N Tsichlis
Journal:  EMBO J       Date:  2002-09-16       Impact factor: 11.598

7.  Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.

Authors:  Vasiliki Koliaraki; Manolis Roulis; George Kollias
Journal:  J Clin Invest       Date:  2012-10-15       Impact factor: 14.808

8.  Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.

Authors:  Lisa A Mielke; Karen L Elkins; Lai Wei; Robyn Starr; Philip N Tsichlis; John J O'Shea; Wendy T Watford
Journal:  J Immunol       Date:  2009-12-15       Impact factor: 5.422

9.  Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription.

Authors:  Lawrence P Kane; Marianne N Mollenauer; Zheng Xu; Christoph W Turck; Arthur Weiss
Journal:  Mol Cell Biol       Date:  2002-08       Impact factor: 4.272

10.  Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

Authors:  Aristides G Eliopoulos; Chun-Chi Wang; Calin D Dumitru; Philip N Tsichlis
Journal:  EMBO J       Date:  2003-08-01       Impact factor: 11.598
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