Literature DB >> 8934437

Visuospatial information processing in intoxicated, recently detoxified, and long-term abstinent alcoholics.

S L Schandler1, A D Clegg, C S Thomas, M J Cohen.   

Abstract

Visuospatial information processing has been shown to be particularly sensitive to acute alcohol intoxication and chronic alcohol abuse. This study extended previous studies by determining if recently detoxified alcoholics recover visuospatial processing after long-term abstinence. If visuospatial function returns to the level displayed by intoxicated alcoholics, then the deficit displayed by recently detoxified alcoholics may represent a short-term adjustment due to the removal of alcohol. However, if the visuospatial deficit remains in long-term abstinent alcoholics, then the superior processing of the intoxicated alcoholic could reflect a normalization of processing produced by alcohol ingestion. Twenty active and 40 recovering alcoholic male volunteers participated. The active alcoholics were seen intoxicated at the time of admission into a 21-day alcohol detoxification and treatment program. Of the recovering alcoholics, 20 were designated as recently detoxified alcoholics and had just completed the same treatment program. The remaining 20 long-term abstinent alcoholics had completed alcohol treatment several years previously with no relapse. Participants selected were similar in general demographic status, alcohol treatment histories, and psychomotor ability. Two main effects emerged from the results: First, the intoxicated alcoholics displayed visuospatial learning that was superior to the learning of alcoholics recently detoxified or abstinent for several years; a second principal finding was nearly identical visuospatial learning displayed by recently detoxified and long-term abstinent alcoholics.

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Year:  1996        PMID: 8934437     DOI: 10.1016/s0899-3289(96)90179-0

Source DB:  PubMed          Journal:  J Subst Abuse        ISSN: 0899-3289


  6 in total

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Authors:  Morris D Bell; Nicholas A Vissicchio; Andrea J Weinstein
Journal:  Drug Alcohol Depend       Date:  2015-12-02       Impact factor: 4.492

2.  Contribution of Regional White Matter Integrity to Visuospatial Construction Accuracy, Organizational Strategy, and Memory for a Complex Figure in Abstinent Alcoholics.

Authors:  Margaret J Rosenbloom; Stephanie A Sassoon; Adolf Pfefferbaum; Edith V Sullivan
Journal:  Brain Imaging Behav       Date:  2009-12-01       Impact factor: 3.978

3.  Rapid cognitive screening of patients with substance use disorders.

Authors:  Marc L Copersino; William Fals-Stewart; Garrett Fitzmaurice; David J Schretlen; Jody Sokoloff; Roger D Weiss
Journal:  Exp Clin Psychopharmacol       Date:  2009-10       Impact factor: 3.157

4.  Repeated diazepam administration reversed working memory impairments and glucocorticoid alterations in the prefrontal cortex after short but not long alcohol-withdrawal periods.

Authors:  G Dominguez; N Henkous; C Pierard; C Belzung; N Mons; Daniel Beracochea
Journal:  Cogn Affect Behav Neurosci       Date:  2018-08       Impact factor: 3.282

Review 5.  Learning and Memory Performance After Withdrawal of Agent Abuse: A Review.

Authors:  Bahareh Amin; Sasan Andalib; Golnaz Vaseghi; Azadeh Mesripour
Journal:  Iran J Psychiatry Behav Sci       Date:  2016-05-21

6.  Double-blind, 12 month follow-up, placebo-controlled trial of mifepristone on cognition in alcoholics: the MIFCOG trial protocol.

Authors:  Kim Donoghue; Abigail Rose; Simon Coulton; Joanna Milward; Kylie Reed; Colin Drummond; Hilary Little
Journal:  BMC Psychiatry       Date:  2016-02-24       Impact factor: 3.630

  6 in total

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