Primary penile lymphoma: the case for combined modality therapy.

A patient with non-Hodgkin's lymphoma with a penile mass as the only apparent site of clinical involvement is presented, and the literature reviewed. Our patient was treated initially with partial penile amputation. A year later the lymphoma recurred in the chest and the right tonsil. Further chemotherapy failed to salvage the patient, who died of disseminated lymphoma. We suggest that, for patients presenting with a lymphomatous penile mass as the initial manifestation of non-Hodgkin's lymphoma, chemotherapy with or without radiotherapy as the initial treatment. Surgery should be reserved only for failures.