PURPOSE: To implement a three-dimensional subtraction functional CT technique to permit rapid quantitative mapping of regional cerebral blood volume (CBV). METHODS: The 3-D functional CT technique was implemented in a rabbit model using normal and ischemic animals. Two spiral data acquisitions were performed, one before and one during biphasic administration of contrast material. CBV maps were then produced on a voxel-by-voxel basis through the whole brain. RESULTS: The average normal CBV was 3.3 +/- 0.4 mL/100 g (n = 7), and the regional values were 4.5 +/- 0.6 mL/100 g for cortical gray matter, 2.5 +/- 0.6 mL/100 g for white matter, and 3.7 +/- 0.4 mL/100 g for the basal ganglia. The CBVs in ischemic regions were 1.5 +/- 0.4 mL/100 g, 0.7 +/- 0.7 mL/100 g, and 1.8 +/- 0.9 mL/100 g, respectively. CONCLUSION: Subtraction 3-D functional CT is a fast, potentially cost-effective method with which to assess whole-brain CBV. Because the data collected in 3-D functional CT imaging also can be used to produce large-vessel angiograms, its use in a clinical setting can provide a multiparametric study of cerebrovascular abnormalities that encompasses both large and small vessel circulations for patients being examined for stroke.
PURPOSE: To implement a three-dimensional subtraction functional CT technique to permit rapid quantitative mapping of regional cerebral blood volume (CBV). METHODS: The 3-D functional CT technique was implemented in a rabbit model using normal and ischemic animals. Two spiral data acquisitions were performed, one before and one during biphasic administration of contrast material. CBV maps were then produced on a voxel-by-voxel basis through the whole brain. RESULTS: The average normal CBV was 3.3 +/- 0.4 mL/100 g (n = 7), and the regional values were 4.5 +/- 0.6 mL/100 g for cortical gray matter, 2.5 +/- 0.6 mL/100 g for white matter, and 3.7 +/- 0.4 mL/100 g for the basal ganglia. The CBVs in ischemic regions were 1.5 +/- 0.4 mL/100 g, 0.7 +/- 0.7 mL/100 g, and 1.8 +/- 0.9 mL/100 g, respectively. CONCLUSION: Subtraction 3-D functional CT is a fast, potentially cost-effective method with which to assess whole-brain CBV. Because the data collected in 3-D functional CT imaging also can be used to produce large-vessel angiograms, its use in a clinical setting can provide a multiparametric study of cerebrovascular abnormalities that encompasses both large and small vessel circulations for patients being examined for stroke.
Authors: Edite Figueiras; Ricardo Oliveira; Cátia F Lourenço; Rita Campos; Anne Humeau-Heurtier; Rui M Barbosa; João Laranjinha; Luis F Requicha Ferreira; Frits F M de Mul Journal: Med Biol Eng Comput Date: 2012-10-12 Impact factor: 2.602
Authors: Benjamin Pulli; Pamela W Schaefer; Reza Hakimelahi; Zeshan A Chaudhry; Michael H Lev; Joshua A Hirsch; R Gilberto González; Albert J Yoo Journal: Radiology Date: 2011-12-20 Impact factor: 11.105
Authors: T Struffert; Y Deuerling-Zheng; S Kloska; T Engelhorn; C M Strother; W A Kalender; M Köhrmann; S Schwab; A Doerfler Journal: AJNR Am J Neuroradiol Date: 2010-04-08 Impact factor: 3.825
Authors: E S Rosenthal; L H Schwamm; L Roccatagliata; S B Coutts; A M Demchuk; P W Schaefer; R G Gonzalez; M D Hill; E F Halpern; M H Lev Journal: AJNR Am J Neuroradiol Date: 2008-07-03 Impact factor: 3.825