J S Duncan1, P Bartlett, G J Barker. 1. MR Unit, National Society for Epilepsy, Institute of Neurology, Bucks, United Kingdom.
Abstract
PURPOSE: To implement and validate methods for producing calculated coronal T2 maps with complete coverage of the hippocampus and the rest of the brain. METHODS: T2 relaxation times were estimated on three occasions for 12 quality assessment test objects with the use of fast spin-echo (FSE) and conventional spin-echo (CSE) sequences. Hippocampal T2 relaxation times were measured in 15 healthy subjects with FSE and CSE sequences. Ten of these subjects were scanned twice with CSE imaging. Twenty-two patients with temporal lobe epilepsy, in whom hippocampal T2 relaxation times were previously estimated by means of a multiecho sequence, were studied with CSE. RESULTS: CSE data were more reliable than FSE data. Reliability of hippocampal T2 measures on repeated acquisitions was superior for the CSE sequence with echo time 30,120 than for the 30,80 sequence (test-retest reliability, 4.0%; interrater reliability, 4.6%). CSE images were suitable for qualitative reporting, so additional T2-weighted sequences were not required. There was good correlation between these hippocampal T2 data and values obtained on a previously validated multiecho technique, with reliable identification of hippocampal sclerosis. CONCLUSION: T2 mapping with CSE 30/120 sequences may be readily applied, produces reliable T2 values in contiguous 5-mm sections, and may be useful in the assessment of the hippocampus and other cerebral structures.
PURPOSE: To implement and validate methods for producing calculated coronal T2 maps with complete coverage of the hippocampus and the rest of the brain. METHODS: T2 relaxation times were estimated on three occasions for 12 quality assessment test objects with the use of fast spin-echo (FSE) and conventional spin-echo (CSE) sequences. Hippocampal T2 relaxation times were measured in 15 healthy subjects with FSE and CSE sequences. Ten of these subjects were scanned twice with CSE imaging. Twenty-two patients with temporal lobe epilepsy, in whom hippocampal T2 relaxation times were previously estimated by means of a multiecho sequence, were studied with CSE. RESULTS: CSE data were more reliable than FSE data. Reliability of hippocampal T2 measures on repeated acquisitions was superior for the CSE sequence with echo time 30,120 than for the 30,80 sequence (test-retest reliability, 4.0%; interrater reliability, 4.6%). CSE images were suitable for qualitative reporting, so additional T2-weighted sequences were not required. There was good correlation between these hippocampal T2 data and values obtained on a previously validated multiecho technique, with reliable identification of hippocampal sclerosis. CONCLUSION: T2 mapping with CSE 30/120 sequences may be readily applied, produces reliable T2 values in contiguous 5-mm sections, and may be useful in the assessment of the hippocampus and other cerebral structures.
Authors: Regula S Briellmann; Ari Syngeniotis; Steve Fleming; Renate M Kalnins; David F Abbott; Graeme D Jackson Journal: AJNR Am J Neuroradiol Date: 2004-03 Impact factor: 3.825
Authors: Nancy A Pike; Bhaswati Roy; Ritika Gupta; Sadhana Singh; Mary A Woo; Nancy J Halnon; Alan B Lewis; Rajesh Kumar Journal: J Neurosci Res Date: 2018-01-06 Impact factor: 4.164
Authors: Jerry S Cheung; Enfeng Wang; XiaoAn Zhang; Emiri Mandeville; Eng H Lo; A Gregory Sorensen; Phillip Zhe Sun Journal: NMR Biomed Date: 2011-07-14 Impact factor: 4.044
Authors: Akshay S Chaudhari; Bragi Sveinsson; Catherine J Moran; Emily J McWalter; Ethan M Johnson; Tao Zhang; Garry E Gold; Brian A Hargreaves Journal: Magn Reson Med Date: 2017-01-11 Impact factor: 4.668
Authors: Sofia H Eriksson; Maria Thom; Mark R Symms; Niels K Focke; Lillian Martinian; Sanjay M Sisodiya; John S Duncan Journal: Hum Brain Mapp Date: 2009-10 Impact factor: 5.038