Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Use of the Syrian hamster embryo cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent bioassays.

Literature DB >> 8933057

Use of the Syrian hamster embryo cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent bioassays.

G A Kerckaert¹, R Brauninger, R A LeBoeuf, R J Isfort.

Abstract

The Syrian hamster embryo (SHE) cell transformation assay was used to predict the carcinogenicity of 26 chemicals currently being tested in the rodent bioassay by the National Toxicology Program as part of its program titled "Strategies for Predicting Chemical Carcinogenesis in Rodents." Of these 26 chemicals, 17 were found to be positive in the SHE cell transformation assay while 9 were negative. Carcinogenicity predictions were made for these chemicals, based upon the SHE cell transformation assay results. Our predictions will be compared with the rodent bioassay results as they become available.

Entities: Species

Mesh：

Substances：
Carcinogens

Year: 1996 PMID： 8933057 PMCID： PMC1469685 DOI： 10.1289/ehp.96104s51075

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

5 in total

1. The progressive nature of neoplastic transformation of Syrian hamster embryo cells in culture.

Authors: J C Barrett
Journal: Prog Exp Tumor Res Date: 1979

2. In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons.

Authors: Y Berwald; L Sachs
Journal: J Natl Cancer Inst Date: 1965-10 Impact factor: 13.506

3. Use of cell transformation systems for carcinogenicity testing and mechanistic studies of carcinogenesis.

Authors: J C Barrett; T W Hesterberg; D G Thomassen
Journal: Pharmacol Rev Date: 1984-06 Impact factor: 25.468

4. An interlaboratory comparison of enhanced morphological transformation of Syrian hamster embryo cells cultured under conditions of reduced bicarbonate concentration and pH.

Authors: R A LeBoeuf; G A Kerckaert; J A Poiley; R Raineri
Journal: Mutat Res Date: 1989-03 Impact factor: 2.433

5. Growth factor responsiveness and alterations in growth factor homeostasis in Syrian hamster embryo cells during in vitro transformation.

Authors: R J Isfort; D B Cody; G A Kerckaert; R A LeBoeuf
Journal: Carcinogenesis Date: 1994-06 Impact factor: 4.944

5 in total

1. The NIEHS Predictive-Toxicology Evaluation Project.

Authors: D W Bristol; J T Wachsman; A Greenwell
Journal: Environ Health Perspect Date: 1996-10 Impact factor: 9.031

2. Comparison of 17 methods of predicting the carcinogenicity of 30 chemicals.

Authors: J Ashby
Journal: Environ Health Perspect Date: 1997-05 Impact factor: 9.031

3. p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing.

Authors: P J Duerksen-Hughes; J Yang; O Ozcan
Journal: Environ Health Perspect Date: 1999-10 Impact factor: 9.031

4. Safety and efficacy of a feed additive consisting of a tincture from the bark of Cinnamomum verum J. Presl (cinnamon tincture) for use in all animal species (FEFANA asbl).

Authors: Vasileios Bampidis; Giovanna Azimonti; Maria de Lourdes Bastos; Henrik Christensen; Mojca Fašmon Durjava; Maryline Kouba; Marta López-Alonso; Secundino López Puente; Francesca Marcon; Baltasar Mayo; Alena Pechová; Mariana Petkova; Fernando Ramos; Yolanda Sanz; Roberto Edoardo Villa; Ruud Woutersen; Paul Brantom; Andrew Chesson; Johannes Westendorf; Paola Manini; Fabiola Pizzo; Birgit Dusemund
Journal: EFSA J Date: 2021-12-09

5. Safety and efficacy of a feed additive consisting of an essential oil from the leaves of Agathosma betulina (P.J. Bergius) Pillans (buchu leaf oil) for use in all animal species (FEFANA asbl).

5 in total