| Literature DB >> 893225 |
R S Egan, R S Stanaszek, M Cirovic, S L Mueller, J Tadanier, J R Martin, P Collum, A W Goldstein, R L De Vault, A C Sinclair, E E Fager, L A Mitscher.
Abstract
The structures of fortimicins A and B have been determined by PMR, CMR, mass spectra and CD combined with chemical degradations. Both antibiotics are pseudodisaccharides and incorporate a novel aminocyclitol, fortamine. In contrast to the diaminocyclitol moieties of known aminoglycosides, fortamine is a 1,4-diamine, contains both N- and O-methyl groups and possesses chiro stereochemistry. Both antibiotics are glycosides of 6-epi-purpurosamine B, but fortimicin A differs from fortimicin B by being a glycyl amide.Entities:
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Year: 1977 PMID： 893225 DOI： 10.7164/antibiotics.30.552
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649