Literature DB >> 8929782

Antacid-induced osteomalacia.

Y Boutsen1, J P Devogelaer, J Malghem, H Noel, C Nagant de Deuxchaisnes.   

Abstract

The case of a 49-year-old woman suffering from generalized skeletal pain and multiple fractures accompanied by severe hypophosphataemia and low urinary phosphorus excretion is reported. She had been taking large amounts of antacids containing aluminum hydroxide for many years. A diagnosis of antacid-induced osteomalacia was made. It was confirmed by biological work-up, radiographs and bone biopsy. A dramatic biological, osteodensitometric, and clinical improvement was achieved by withdrawal of antacids and phosphorus administration. The literature concerning this unusual condition has been reviewed.

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Year:  1996        PMID: 8929782     DOI: 10.1007/bf02231691

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN: 0770-3198            Impact factor:   2.980


  24 in total

1.  Production of hypercalciuria by phosphorus deprivation on a low calcium intake: a new clinical test for hyperparathyroidism.

Authors:  P PRONOVE; N H BELL; F C BARTTER
Journal:  Metabolism       Date:  1961-05       Impact factor: 8.694

2.  Osteomalacia due to phosphate depletion from excessive aluminium hydroxide ingestion.

Authors:  C E Dent; C S Winter
Journal:  Br Med J       Date:  1974-03-23

3.  "Tertiary" hyperparathyroidism induced by osteomalacia resulting from phosphorus depletion.

Authors:  G D Ludwig; C G Kyle; M de Blanco
Journal:  Am J Med       Date:  1967-07       Impact factor: 4.965

4.  Hypophosphatemic rickets with hypocalciuria following long-term treatment with aluminum-containing antacid.

Authors:  J Foldes; R Balena; A Ho; A M Parfitt; M Kleerekoper
Journal:  Bone       Date:  1991       Impact factor: 4.398

Review 5.  Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.

Authors:  A Chines; R Pacifici
Journal:  Calcif Tissue Int       Date:  1990-11       Impact factor: 4.333

6.  Phosphate deprivation increases serum 1,25-(OH)2-vitamin D concentrations in healthy men.

Authors:  W J Maierhofer; R W Gray; J Lemann
Journal:  Kidney Int       Date:  1984-03       Impact factor: 10.612

7.  Osteomalacia from Al and Mg antacids. Report of a case of bilateral hip fracture.

Authors:  L Neumann; B G Jensen
Journal:  Acta Orthop Scand       Date:  1989-06

8.  Phosphate-binding properties and electrolyte content of aluminum hydroxide antacids.

Authors:  R W Balasa; R L Murray; N P Kondelis; M D Bischel
Journal:  Nephron       Date:  1987       Impact factor: 2.847

9.  Iatrogenic osteomalacia and myopathy due to phosphate depletion.

Authors:  L R Baker; P Ackrill; W R Cattell; T C Stamp; L Watson
Journal:  Br Med J       Date:  1974-07-20

Review 10.  Phosphate depletion syndrome: case report with bone and muscle histology findings and review of the literature.

Authors:  Y Levy; M Bansal; D A Zackson; J Lane; M Shike
Journal:  JPEN J Parenter Enteral Nutr       Date:  1988 May-Jun       Impact factor: 4.016

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  2 in total

1.  Vitamin D deficiency among northern Native Peoples: a real or apparent problem?

Authors:  Peter Frost
Journal:  Int J Circumpolar Health       Date:  2012-03-19       Impact factor: 1.228

2.  Bone histomorphometry in the evaluation of osteomalacia.

Authors:  Arti Bhan; Shijing Qiu; Sudhaker D Rao
Journal:  Bone Rep       Date:  2018-03-17
  2 in total

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